CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES
Contrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid–polyethylene glycol (PL–P...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2014-01-01
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| Series: | Journal of Innovative Optical Health Sciences |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/pdf/10.1142/S1793545813500296 |
| _version_ | 1811232457376137216 |
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| author | JUNPING ZHONG SIHUA YANG |
| author_facet | JUNPING ZHONG SIHUA YANG |
| author_sort | JUNPING ZHONG |
| collection | DOAJ |
| description | Contrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid–polyethylene glycol (PL–PEG), entitled ICG–PL–PEG nanoparticles. These nanoparticles have overcome numerous limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation and lack of target specificity. ICG–PL–PEG nanoparticles are biocompatible and relatively nontoxic. All the components of ICG–PL–PEG nanoparticles have been approved for human use. Upon pulsed laser irradiation, the nanoparticles are more efficient in producing photoacoustic waves than ICG alone. The results showed that ICG–PL–PEG nanoparticles act as good contrast agents for photoacoustic imaging. These unique ICG–PL–PEG nanoparticles have great potential in clinical applications. |
| first_indexed | 2024-04-12T11:04:10Z |
| format | Article |
| id | doaj.art-19c08a35532f44c78c7e4471737bb9ee |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-04-12T11:04:10Z |
| publishDate | 2014-01-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-19c08a35532f44c78c7e4471737bb9ee2022-12-22T03:35:51ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052014-01-01711350029-11350029-710.1142/S179354581350029610.1142/S1793545813500296CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLESJUNPING ZHONG0SIHUA YANG1MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631, P. R. ChinaMOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631, P. R. ChinaContrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid–polyethylene glycol (PL–PEG), entitled ICG–PL–PEG nanoparticles. These nanoparticles have overcome numerous limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation and lack of target specificity. ICG–PL–PEG nanoparticles are biocompatible and relatively nontoxic. All the components of ICG–PL–PEG nanoparticles have been approved for human use. Upon pulsed laser irradiation, the nanoparticles are more efficient in producing photoacoustic waves than ICG alone. The results showed that ICG–PL–PEG nanoparticles act as good contrast agents for photoacoustic imaging. These unique ICG–PL–PEG nanoparticles have great potential in clinical applications.http://www.worldscientific.com/doi/pdf/10.1142/S1793545813500296Photoacoustic imagingnanoparticleindocyanine greenphospholipid–polyethylene glycol |
| spellingShingle | JUNPING ZHONG SIHUA YANG CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES Journal of Innovative Optical Health Sciences Photoacoustic imaging nanoparticle indocyanine green phospholipid–polyethylene glycol |
| title | CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES |
| title_full | CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES |
| title_fullStr | CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES |
| title_full_unstemmed | CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES |
| title_short | CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES |
| title_sort | contrast enhanced photoacoustic imaging using indocyanine green containing nanoparticles |
| topic | Photoacoustic imaging nanoparticle indocyanine green phospholipid–polyethylene glycol |
| url | http://www.worldscientific.com/doi/pdf/10.1142/S1793545813500296 |
| work_keys_str_mv | AT junpingzhong contrastenhancedphotoacousticimagingusingindocyaninegreencontainingnanoparticles AT sihuayang contrastenhancedphotoacousticimagingusingindocyaninegreencontainingnanoparticles |