Use of Deep‐Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin‐Induced Cardiotoxicity

Use of Deep‐Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin‐Induced Cardiotoxicity

Abstract Doxorubicin‐induced cardiomyopathy (DIC) brings tough clinical challenges as well as continued demand in developing agents for adjuvant cardioprotective therapies. Here, a zebrafish phenotypic screening with deep‐learning assisted multiplex cardiac functional analysis using motion videos of...

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Bibliographic Details
Main Authors: Changtong Liu, Yingchao Wang, Yixin Zeng, Zirong Kang, Hong Zhao, Kun Qi, Hongzhi Wu, Lu Zhao, Yi Wang
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
cyanidin chloride
deep learning
doxorubicin
Keap1‐Nrf2 interaction
zebrafish phenotypic screen
Online Access:https://doi.org/10.1002/advs.202301136

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