Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis
Abstract Background Platelets play an important role in the development of cardiovascular disease (CVD). Mean platelet volume (MPV) is considered as biological marker of platelets activity and function. The aim of the present study was to evaluate MPV values and its possible correlation with arteria...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-024-02177-3 |
| _version_ | 1827328733618372608 |
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| author | Velia Cassano Giuseppe Armentaro Domenico Iembo Sofia Miceli Teresa V. Fiorentino Elena Succurro Maria Perticone Franco Arturi Marta L. Hribal Tiziana Montalcini Francesco Andreozzi Giorgio Sesti Arturo Pujia Angela Sciacqua |
| author_facet | Velia Cassano Giuseppe Armentaro Domenico Iembo Sofia Miceli Teresa V. Fiorentino Elena Succurro Maria Perticone Franco Arturi Marta L. Hribal Tiziana Montalcini Francesco Andreozzi Giorgio Sesti Arturo Pujia Angela Sciacqua |
| author_sort | Velia Cassano |
| collection | DOAJ |
| description | Abstract Background Platelets play an important role in the development of cardiovascular disease (CVD). Mean platelet volume (MPV) is considered as biological marker of platelets activity and function. The aim of the present study was to evaluate MPV values and its possible correlation with arterial stiffness and subclinical myocardial damage, in normal glucose tolerance patients (NGT), in newly diagnosed type 2 diabetic (T2DM) patients and in individuals with pre-diabetes. Methods We enrolled 400 newly diagnosed hypertensive patients. All patients underwent an Oral Glucose Tolerance test (OGTT). Arterial stiffness (AS) was evaluated with the measurement of carotid-femoral pulse wave velocity (PWV), augmentation pressure (AP) and augmentation index (AI). Echocardiographic recordings were performed using an E-95 Pro ultrasound system. Results Among groups there was an increase in fasting plasma glucose (FPG) (p < 0.0001), fasting plasma insulin (FPI) (p < 0.0001), high sensitivity c reactive protein (hs-CRP) levels (p < 0.0001) and a decrease in renal function as demonstrated by e-GFR values (p < 0.0001). From the NGT group to the T2DM group there was a rise in MPV value (p < 0.0001). Moreover, in the evaluation of arterial stiffness and subclinical myocardial damage, MPV showed a positive correlation with these parameters. Conclusions In the present study we highlighted that MPV is significantly increased, not only in newly diagnosed T2DM patients, but also in early stage of diabetes, indicating that subjects with pre-diabetes present increased platelets reactivity. Moreover, our results suggest that MPV is associated with increased arterial stiffness and subclinical myocardial damage, indicating MPV as new marker of CV risk. |
| first_indexed | 2024-03-07T15:21:35Z |
| format | Article |
| id | doaj.art-19c4e96807734258a0f95be448884d3f |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-07T15:21:35Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-19c4e96807734258a0f95be448884d3f2024-03-05T17:36:47ZengBMCCardiovascular Diabetology1475-28402024-03-0123111010.1186/s12933-024-02177-3Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasisVelia Cassano0Giuseppe Armentaro1Domenico Iembo2Sofia Miceli3Teresa V. Fiorentino4Elena Succurro5Maria Perticone6Franco Arturi7Marta L. Hribal8Tiziana Montalcini9Francesco Andreozzi10Giorgio Sesti11Arturo Pujia12Angela Sciacqua13Department of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroResearch Center for the Prevention and Treatment of Metabolic Diseases (CR METDIS), University “Magna Graecia” of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Clinical and Molecular Medicine, Sapienza University of RomeDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroDepartment of Medical and Surgical Sciences, University Magna Graecia of CatanzaroAbstract Background Platelets play an important role in the development of cardiovascular disease (CVD). Mean platelet volume (MPV) is considered as biological marker of platelets activity and function. The aim of the present study was to evaluate MPV values and its possible correlation with arterial stiffness and subclinical myocardial damage, in normal glucose tolerance patients (NGT), in newly diagnosed type 2 diabetic (T2DM) patients and in individuals with pre-diabetes. Methods We enrolled 400 newly diagnosed hypertensive patients. All patients underwent an Oral Glucose Tolerance test (OGTT). Arterial stiffness (AS) was evaluated with the measurement of carotid-femoral pulse wave velocity (PWV), augmentation pressure (AP) and augmentation index (AI). Echocardiographic recordings were performed using an E-95 Pro ultrasound system. Results Among groups there was an increase in fasting plasma glucose (FPG) (p < 0.0001), fasting plasma insulin (FPI) (p < 0.0001), high sensitivity c reactive protein (hs-CRP) levels (p < 0.0001) and a decrease in renal function as demonstrated by e-GFR values (p < 0.0001). From the NGT group to the T2DM group there was a rise in MPV value (p < 0.0001). Moreover, in the evaluation of arterial stiffness and subclinical myocardial damage, MPV showed a positive correlation with these parameters. Conclusions In the present study we highlighted that MPV is significantly increased, not only in newly diagnosed T2DM patients, but also in early stage of diabetes, indicating that subjects with pre-diabetes present increased platelets reactivity. Moreover, our results suggest that MPV is associated with increased arterial stiffness and subclinical myocardial damage, indicating MPV as new marker of CV risk.https://doi.org/10.1186/s12933-024-02177-3Mean platelets volumeType 2 diabetesPre-diabetesArterial stiffnessGlobal longitudinal strain |
| spellingShingle | Velia Cassano Giuseppe Armentaro Domenico Iembo Sofia Miceli Teresa V. Fiorentino Elena Succurro Maria Perticone Franco Arturi Marta L. Hribal Tiziana Montalcini Francesco Andreozzi Giorgio Sesti Arturo Pujia Angela Sciacqua Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis Cardiovascular Diabetology Mean platelets volume Type 2 diabetes Pre-diabetes Arterial stiffness Global longitudinal strain |
| title | Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis |
| title_full | Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis |
| title_fullStr | Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis |
| title_full_unstemmed | Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis |
| title_short | Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis |
| title_sort | mean platelet volume mpv as new marker of diabetic macrovascular complications in patients with different glucose homeostasis |
| topic | Mean platelets volume Type 2 diabetes Pre-diabetes Arterial stiffness Global longitudinal strain |
| url | https://doi.org/10.1186/s12933-024-02177-3 |
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