Simultaneous Ligand and Receptor Tracking through NMR Spectroscopy Enabled by Distinct <sup>19</sup>F Labels

Simultaneous Ligand and Receptor Tracking through NMR Spectroscopy Enabled by Distinct <sup>19</sup>F Labels

To probe ligand-receptor binding at the atomic-level, a frequent approach involves multidimensional nuclear magnetic resonance (NMR) spectroscopy experiments relying on <sup>13</sup>C- and/or <sup>15</sup>N-enrichment alongside <sup>1</sup>H. Alternatively, the la...

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Bibliographic Details
Main Authors: Jeffrey R. Simmons, Alexandre Murza, Michael D. Lumsden, Calem Kenward, Éric Marsault, Jan K. Rainey
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
<sup>19</sup>F NMR
G protein-coupled receptor (GPCR)
apelin receptor (APJ)
ligand-receptor interactions
peptide-GPCR binding
<sup>19</sup>F-labelled apelin analogues
Online Access:https://www.mdpi.com/1422-0067/20/15/3658

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https://www.mdpi.com/1422-0067/20/15/3658

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