Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction
INTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in patients treated with β-blockers could at least in part explain th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2010-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000300005 |
| _version_ | 1811228655666331648 |
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| author | Antonio Eduardo Pesaro Alexandre de Matos Soeiro Carlos Vicente Serrano Roberto Rocha Giraldez Renata Teixeira Ladeira José Carlos Nicolau |
| author_facet | Antonio Eduardo Pesaro Alexandre de Matos Soeiro Carlos Vicente Serrano Roberto Rocha Giraldez Renata Teixeira Ladeira José Carlos Nicolau |
| author_sort | Antonio Eduardo Pesaro |
| collection | DOAJ |
| description | INTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in patients treated with β-blockers could at least in part explain the benefits of this drug. OBJECTIVE: To investigate the effect of β-blockers on the incidence of atrial fibrillation in patients with acute myocardial infarction. METHODS: We analyzed 1401 patients with acute myocardial infarction and evaluated the occurrence or absence of atrial fibrillation, the use of oral β-blockers and mortality during the first 24 hours. RESULTS: a) The use of β-blockers was inversely correlated with the presence of atrial fibrillation (ρ = 0.004; OR = 0.54). b) Correlations with mortality were as follows: 31.5% in patients with atrial fibrillation, 9.2% in those without atrial fibrillation (ρ < 0.001; Odds Ratio = 4.52), and 17.5% in patients not treated with β-blockers and 6.7% in those who received the drug (ρ < 0.001; OR = 0.34). c) Adjusted Models: The presence of atrial fibrillation was independently correlated with mortality (OR = 2.48, ρ = 0.002). The use of β-blockers was inversely and independently correlated with mortality (OR = 0.53; ρ = 0.002). The patients who used β-blockers showed a lower risk of atrial fibrillation (OR = 0.59; ρ = 0.029) in the adjusted model. CONCLUSION: The presence of atrial fibrillation and the absence of oral β-blockers increased in-hospital mortality in patients with acute myocardial infarction. Oral β-blockers reduced the incidence of atrial fibrillation, which might be at least partially responsible for the drug's benefit. |
| first_indexed | 2024-04-12T10:01:33Z |
| format | Article |
| id | doaj.art-19c95277f63c415e831a03316cad62e4 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:01:33Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-19c95277f63c415e831a03316cad62e42022-12-22T03:37:33ZengElsevier EspañaClinics1807-59321980-53222010-01-0165326527010.1590/S1807-59322010000300005Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarctionAntonio Eduardo PesaroAlexandre de Matos SoeiroCarlos Vicente SerranoRoberto Rocha GiraldezRenata Teixeira LadeiraJosé Carlos NicolauINTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in patients treated with β-blockers could at least in part explain the benefits of this drug. OBJECTIVE: To investigate the effect of β-blockers on the incidence of atrial fibrillation in patients with acute myocardial infarction. METHODS: We analyzed 1401 patients with acute myocardial infarction and evaluated the occurrence or absence of atrial fibrillation, the use of oral β-blockers and mortality during the first 24 hours. RESULTS: a) The use of β-blockers was inversely correlated with the presence of atrial fibrillation (ρ = 0.004; OR = 0.54). b) Correlations with mortality were as follows: 31.5% in patients with atrial fibrillation, 9.2% in those without atrial fibrillation (ρ < 0.001; Odds Ratio = 4.52), and 17.5% in patients not treated with β-blockers and 6.7% in those who received the drug (ρ < 0.001; OR = 0.34). c) Adjusted Models: The presence of atrial fibrillation was independently correlated with mortality (OR = 2.48, ρ = 0.002). The use of β-blockers was inversely and independently correlated with mortality (OR = 0.53; ρ = 0.002). The patients who used β-blockers showed a lower risk of atrial fibrillation (OR = 0.59; ρ = 0.029) in the adjusted model. CONCLUSION: The presence of atrial fibrillation and the absence of oral β-blockers increased in-hospital mortality in patients with acute myocardial infarction. Oral β-blockers reduced the incidence of atrial fibrillation, which might be at least partially responsible for the drug's benefit.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000300005Acute myocardial infarctionβ-blockersAtrial fibrillationMortalityArrhythmias |
| spellingShingle | Antonio Eduardo Pesaro Alexandre de Matos Soeiro Carlos Vicente Serrano Roberto Rocha Giraldez Renata Teixeira Ladeira José Carlos Nicolau Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction Clinics Acute myocardial infarction β-blockers Atrial fibrillation Mortality Arrhythmias |
| title | Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
| title_full | Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
| title_fullStr | Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
| title_full_unstemmed | Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
| title_short | Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
| title_sort | effect of 946 blockers on the risk of atrial fibrillation in patients with acute myocardial infarction |
| topic | Acute myocardial infarction β-blockers Atrial fibrillation Mortality Arrhythmias |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010000300005 |
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