Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation
Summary: The hippocampal mossy fiber (MF) synapse has been implicated in the pathophysiology and treatment of psychiatric disorders. Alterations of dopaminergic and serotonergic modulations at this synapse are candidate mechanisms underlying antidepressant and other related treatments. However, thes...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220302091 |
| _version_ | 1818962163416432640 |
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| author | Katsunori Kobayashi Yasunori Mikahara Yuka Murata Daiki Morita Sumire Matsuura Eri Segi-Nishida Hidenori Suzuki |
| author_facet | Katsunori Kobayashi Yasunori Mikahara Yuka Murata Daiki Morita Sumire Matsuura Eri Segi-Nishida Hidenori Suzuki |
| author_sort | Katsunori Kobayashi |
| collection | DOAJ |
| description | Summary: The hippocampal mossy fiber (MF) synapse has been implicated in the pathophysiology and treatment of psychiatric disorders. Alterations of dopaminergic and serotonergic modulations at this synapse are candidate mechanisms underlying antidepressant and other related treatments. However, these monoaminergic modulations share the intracellular signaling pathway at the MF synapse, which implies redundancy in their functions. We here show that endogenous monoamines can potentiate MF synaptic transmission in mouse hippocampal slices by activating the serotonin 5-HT4 receptor. Dopamine receptors were not effectively activated by endogenous agonists, suggesting that the dopaminergic modulation is latent. Electroconvulsive treatment enhanced the 5-HT4 receptor-mediated serotonergic synaptic potentiation specifically at the MF synapse, increased the hippocampal serotonin content, and produced an anxiolytic-like behavioral effect in a 5-HT4 receptor-dependent manner. These results suggest that serotonin plays a predominant role in monoaminergic modulations at the MF synapse. Augmentation of this serotonergic modulation may mediate anxiolytic effects of electroconvulsive treatment. : Physiology; Neuroscience; Neuroanatomy; Behavioral Neuroscience Subject Areas: Physiology, Neuroscience, Neuroanatomy, Behavioral Neuroscience |
| first_indexed | 2024-12-20T12:24:57Z |
| format | Article |
| id | doaj.art-19ca920428774f1e981c2f29d80138ae |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-20T12:24:57Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-19ca920428774f1e981c2f29d80138ae2022-12-21T19:40:53ZengElsevieriScience2589-00422020-04-01234Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic ModulationKatsunori Kobayashi0Yasunori Mikahara1Yuka Murata2Daiki Morita3Sumire Matsuura4Eri Segi-Nishida5Hidenori Suzuki6Department of Pharmacology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan; Corresponding authorDepartment of Pharmacology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, JapanDepartment of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Tokyo 125-8585, JapanDepartment of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Tokyo 125-8585, JapanDepartment of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Tokyo 125-8585, JapanDepartment of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Tokyo 125-8585, JapanDepartment of Pharmacology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, JapanSummary: The hippocampal mossy fiber (MF) synapse has been implicated in the pathophysiology and treatment of psychiatric disorders. Alterations of dopaminergic and serotonergic modulations at this synapse are candidate mechanisms underlying antidepressant and other related treatments. However, these monoaminergic modulations share the intracellular signaling pathway at the MF synapse, which implies redundancy in their functions. We here show that endogenous monoamines can potentiate MF synaptic transmission in mouse hippocampal slices by activating the serotonin 5-HT4 receptor. Dopamine receptors were not effectively activated by endogenous agonists, suggesting that the dopaminergic modulation is latent. Electroconvulsive treatment enhanced the 5-HT4 receptor-mediated serotonergic synaptic potentiation specifically at the MF synapse, increased the hippocampal serotonin content, and produced an anxiolytic-like behavioral effect in a 5-HT4 receptor-dependent manner. These results suggest that serotonin plays a predominant role in monoaminergic modulations at the MF synapse. Augmentation of this serotonergic modulation may mediate anxiolytic effects of electroconvulsive treatment. : Physiology; Neuroscience; Neuroanatomy; Behavioral Neuroscience Subject Areas: Physiology, Neuroscience, Neuroanatomy, Behavioral Neurosciencehttp://www.sciencedirect.com/science/article/pii/S2589004220302091 |
| spellingShingle | Katsunori Kobayashi Yasunori Mikahara Yuka Murata Daiki Morita Sumire Matsuura Eri Segi-Nishida Hidenori Suzuki Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation iScience |
| title | Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation |
| title_full | Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation |
| title_fullStr | Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation |
| title_full_unstemmed | Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation |
| title_short | Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation |
| title_sort | predominant role of serotonin at the hippocampal mossy fiber synapse with redundant monoaminergic modulation |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220302091 |
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