Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain
Background: Chemotherapy induced neuropathy pain remains as a major dose limiting side effect of many commonly used chemotherapeutic drugs. Presently newer antiepileptic agents have been developed with improved safety and tolerability profiles in alleviating neuropathic pain. Objectives: To eva...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5955/13373_[Ra]_F(P)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818271213346095104 |
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| author | A.Mangaiarkkarasi S. Rameshkannan R.Meher Ali |
| author_facet | A.Mangaiarkkarasi S. Rameshkannan R.Meher Ali |
| author_sort | A.Mangaiarkkarasi |
| collection | DOAJ |
| description | Background: Chemotherapy induced neuropathy pain remains
as a major dose limiting side effect of many commonly used
chemotherapeutic drugs. Presently newer antiepileptic agents
have been developed with improved safety and tolerability
profiles in alleviating neuropathic pain.
Objectives: To evaluate the effect of Gabapentin and Pregabalin
in Paclitaxel (Taxol) induced neuropathic pain and to compare
the effect of these drugs in animal models.
Materials and Methods: Rats were randomly divided into
four groups of six animals each. Group 1- vehicle, Group 2
– Paclitaxel (2mg/kg), Group 3 - Gabapentin (60mg/kg) with
Paclitaxel, Group 4 - Pregabalin (30mg/kg) with Paclitaxel.
Pain was induced by intraperitoneal injection of Paclitaxel
on four alternate days. After taking the baseline values, the
drugs treated groups (group 3 and 4) were administered with
respective drugs once a day orally for eight consecutive days
along with paclitaxel. All the animals were tested for thermal
hyperalgesia and cold allodynia on day 0, 7, 14, 21 and 28 with
Radiant heat method and Tail immersion test, Acetone drop
method respectively.
Results: In Radiant heat method, gabapentin and pregabalin
treated animals found to have significant increase in the tail
latency period compared to control and paclitaxel treated
groups in all periods of observation. Acetone drop test and
tail immersion test also showed significant response similar
to Radiant heat method. Pregabalin showed highly significant
effect when compared to gabapentin group.
Conclusion: Both gabapentin and pregabalin produced significant anti-hyperalgesic and anti-allodynic effects in experimental
animal models. Pregabalin treated group showed highly significant effect compared to gabapentin treated animals. |
| first_indexed | 2024-12-12T21:22:36Z |
| format | Article |
| id | doaj.art-19ccd44377ae40399c59f9eefe1464ac |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T21:22:36Z |
| publishDate | 2015-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-19ccd44377ae40399c59f9eefe1464ac2022-12-22T00:11:31ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-05-0195FF11FF1410.7860/JCDR/2015/13373.5955Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic PainA.Mangaiarkkarasi0S. Rameshkannan1R.Meher Ali2Professor, Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.Postgraduate, Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.Professor and Head, Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.Background: Chemotherapy induced neuropathy pain remains as a major dose limiting side effect of many commonly used chemotherapeutic drugs. Presently newer antiepileptic agents have been developed with improved safety and tolerability profiles in alleviating neuropathic pain. Objectives: To evaluate the effect of Gabapentin and Pregabalin in Paclitaxel (Taxol) induced neuropathic pain and to compare the effect of these drugs in animal models. Materials and Methods: Rats were randomly divided into four groups of six animals each. Group 1- vehicle, Group 2 – Paclitaxel (2mg/kg), Group 3 - Gabapentin (60mg/kg) with Paclitaxel, Group 4 - Pregabalin (30mg/kg) with Paclitaxel. Pain was induced by intraperitoneal injection of Paclitaxel on four alternate days. After taking the baseline values, the drugs treated groups (group 3 and 4) were administered with respective drugs once a day orally for eight consecutive days along with paclitaxel. All the animals were tested for thermal hyperalgesia and cold allodynia on day 0, 7, 14, 21 and 28 with Radiant heat method and Tail immersion test, Acetone drop method respectively. Results: In Radiant heat method, gabapentin and pregabalin treated animals found to have significant increase in the tail latency period compared to control and paclitaxel treated groups in all periods of observation. Acetone drop test and tail immersion test also showed significant response similar to Radiant heat method. Pregabalin showed highly significant effect when compared to gabapentin group. Conclusion: Both gabapentin and pregabalin produced significant anti-hyperalgesic and anti-allodynic effects in experimental animal models. Pregabalin treated group showed highly significant effect compared to gabapentin treated animals.https://jcdr.net/articles/PDF/5955/13373_[Ra]_F(P)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfacetone drop methodcold allodyniapaclitaxelradiant heattail immersionthermal hyperalgesia |
| spellingShingle | A.Mangaiarkkarasi S. Rameshkannan R.Meher Ali Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain Journal of Clinical and Diagnostic Research acetone drop method cold allodynia paclitaxel radiant heat tail immersion thermal hyperalgesia |
| title | Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain |
| title_full | Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain |
| title_fullStr | Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain |
| title_full_unstemmed | Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain |
| title_short | Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain |
| title_sort | effect of gabapentin and pregabalin in rat model of taxol induced neuropathic pain |
| topic | acetone drop method cold allodynia paclitaxel radiant heat tail immersion thermal hyperalgesia |
| url | https://jcdr.net/articles/PDF/5955/13373_[Ra]_F(P)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| work_keys_str_mv | AT amangaiarkkarasi effectofgabapentinandpregabalininratmodeloftaxolinducedneuropathicpain AT srameshkannan effectofgabapentinandpregabalininratmodeloftaxolinducedneuropathicpain AT rmeherali effectofgabapentinandpregabalininratmodeloftaxolinducedneuropathicpain |