Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses

Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses

In this study, we investigated the functional role of isoprenylcysteine carboxyl methyltransferase (ICMT) and its methylatable substrate Ras in Toll-like receptor (TLR)-activated macrophages and in mouse inflammatory disease conditions. <i>ICMT</i> and <i>RAS</i> expressions...

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Bibliographic Details
Main Authors: Woo Seok Yang, Han Gyung Kim, Eunji Kim, Sang Yun Han, Nur Aziz, Young-Su Yi, Sunggyu Kim, Yunmi Lee, Byong Chul Yoo, Jeung-Whan Han, Narayanan Parameswaran, Ji Hye Kim, Jae Youl Cho
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
Ras
isoprenylcysteine carboxyl methyltransferase
inflammation
TIR domain
AP-1 pathway
Online Access:https://www.mdpi.com/2073-4409/9/5/1216

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