Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.

Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.

M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis. Thus, control of MPF activity via inhibitory phosphorylation is...

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Bibliographic Details
Main Authors: Vincenzo D'Angiolella, Luca Palazzo, Concetta Santarpia, Vincenzo Costanzo, Domenico Grieco
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-02-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0000247

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