HepT1-derived murine models of high-risk hepatoblastoma display vascular invasion, metastasis, and circulating tumor cells

HepT1-derived murine models of high-risk hepatoblastoma display vascular invasion, metastasis, and circulating tumor cells

Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models that show high-risk features including multifocal t...

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Bibliographic Details
Main Authors: Sarah E. Woodfield, Brandon J. Mistretta, Roma H. Patel, Aryana M. Ibarra, Kevin E. Fisher, Stephen F. Sarabia, Ilavarasi Gandhi, Jacquelyn Reuther, Zbigniew Starosolski, Andrew Badachhape, Jessica Epps, Barry Zorman, Aayushi P. Shah, Samuel R. Larson, Rohit K. Srivastava, Yan Shi, Andres F. Espinoza, Saiabhiroop R. Govindu, Richard S. Whitlock, Kimberly Holloway, Angshumoy Roy, Pavel Sumazin, Ketan B. Ghaghada, Dolores Lopez-Terrada, Preethi H. Gunaratne, Sanjeev A. Vasudevan
Format: Article
Language:English
Published: The Company of Biologists 2022-09-01
Series:Biology Open
Subjects:
hepatoblastoma
pediatric liver cancer
mouse model
invasion
metastasis
circulating tumor cell
Online Access:http://bio.biologists.org/content/11/9/bio058973

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