The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis
Objective: The data for oligoclonal bands (OCB) in cerebrospinal fluid (CSF) and their association with clinical profiles of patients with multiple sclerosis (MS) are limited. In this study, we aimed to investigate the relationship between OCB and clinical and magnetic resonance imaging (MRI) featur...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-12-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjn&un=TJN-72558 |
| _version_ | 1797916893212835840 |
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| author | Nurhan Kaya Tutar Elif Söylemez Sami Ömerhoca Nilüfer Kale İçen |
| author_facet | Nurhan Kaya Tutar Elif Söylemez Sami Ömerhoca Nilüfer Kale İçen |
| author_sort | Nurhan Kaya Tutar |
| collection | DOAJ |
| description | Objective: The data for oligoclonal bands (OCB) in cerebrospinal fluid (CSF) and their association with clinical profiles of patients with multiple sclerosis (MS) are limited. In this study, we aimed to investigate the relationship between OCB and clinical and magnetic resonance imaging (MRI) features in patients with MS. Materials and Methods: Patients between the ages of 18-65 who were diagnosed as having MS in the first 3 months of the onset of the disease were included. The difference between the clinical (gender, age of onset of disease, clinical presentation and subtypes of disease) and MRI characteristics as well as the choice of the treatment regimen of OCB-positive and negative patients were evaluated. The data of the patients were obtained retrospectively from our hospital records. Results: Sixty-four patients who met the criteria were included in the study. Two groups were formed. Group 1 involved 50 OCB positive patients with MS and group 2 involved 14 OCB negative patients with MS. In CSF parameters, cell number (p=0.001), and IgG index were statistically significantly higher in OCB (+) patients compared to OCB (-) patients (p<0.001). In MRI, higher lesion number in the lower cervical spinal segment was found in OCB (+) patients compared to OCB (-) patients. There were no significant differences between OCB (+) and (-) patients with MS in relation to the course of the disease, symptoms of the first attack and severity, relapse rate, or disease modifying therapy. Conclusion: Our results showed that the presence of OCB had a negative effect on MRI in patients with MS. Larger studies are warranted in patients with MS. |
| first_indexed | 2024-04-10T13:04:32Z |
| format | Article |
| id | doaj.art-19d2737e7c9c41c887b1c739d71f9b01 |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T13:04:32Z |
| publishDate | 2022-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-19d2737e7c9c41c887b1c739d71f9b012023-02-15T16:13:00ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452022-12-0128421722210.4274/tnd.2022.72558TJN-72558The Effect of Oligoclonal Bands in Patients with Multiple SclerosisNurhan Kaya Tutar0Elif Söylemez1Sami Ömerhoca2Nilüfer Kale İçen3University of Health Sciences Turkey, Istanbul Bagcilar Training and Research Hospital, Clinic of Neurology, Istanbul, TurkeyUniversity of Health Sciences Turkey, Istanbul Bagcilar Training and Research Hospital, Clinic of Neurology, Istanbul, TurkeyUniversity of Health Sciences Turkey, Istanbul Bagcilar Training and Research Hospital, Clinic of Neurology, Istanbul, TurkeyUniversity of Health Sciences Turkey, Istanbul Bagcilar Training and Research Hospital, Clinic of Neurology, Istanbul, TurkeyObjective: The data for oligoclonal bands (OCB) in cerebrospinal fluid (CSF) and their association with clinical profiles of patients with multiple sclerosis (MS) are limited. In this study, we aimed to investigate the relationship between OCB and clinical and magnetic resonance imaging (MRI) features in patients with MS. Materials and Methods: Patients between the ages of 18-65 who were diagnosed as having MS in the first 3 months of the onset of the disease were included. The difference between the clinical (gender, age of onset of disease, clinical presentation and subtypes of disease) and MRI characteristics as well as the choice of the treatment regimen of OCB-positive and negative patients were evaluated. The data of the patients were obtained retrospectively from our hospital records. Results: Sixty-four patients who met the criteria were included in the study. Two groups were formed. Group 1 involved 50 OCB positive patients with MS and group 2 involved 14 OCB negative patients with MS. In CSF parameters, cell number (p=0.001), and IgG index were statistically significantly higher in OCB (+) patients compared to OCB (-) patients (p<0.001). In MRI, higher lesion number in the lower cervical spinal segment was found in OCB (+) patients compared to OCB (-) patients. There were no significant differences between OCB (+) and (-) patients with MS in relation to the course of the disease, symptoms of the first attack and severity, relapse rate, or disease modifying therapy. Conclusion: Our results showed that the presence of OCB had a negative effect on MRI in patients with MS. Larger studies are warranted in patients with MS.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjn&un=TJN-72558multiple sclerosisbiomarkersoligoclonal bandsimaging |
| spellingShingle | Nurhan Kaya Tutar Elif Söylemez Sami Ömerhoca Nilüfer Kale İçen The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis Türk Nöroloji Dergisi multiple sclerosis biomarkers oligoclonal bands imaging |
| title | The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis |
| title_full | The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis |
| title_fullStr | The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis |
| title_full_unstemmed | The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis |
| title_short | The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis |
| title_sort | effect of oligoclonal bands in patients with multiple sclerosis |
| topic | multiple sclerosis biomarkers oligoclonal bands imaging |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjn&un=TJN-72558 |
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