Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review
Oral squamous cell carcinoma (OSCC) is a complex disease with a high potential for lymph node metastasis and poor survival rates. Accurate nodal staging is crucial for prognostic assessment and treatment planning in OSCC. Recent research has suggested that nodal tumor volume (NTV) may be a more accu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Oral Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2023.1229931/full |
| _version_ | 1828717821502160896 |
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| author | Mischa Bernasconi Ante Bilic Martin Kauke-Navarro Ali-Farid Safi Ali-Farid Safi |
| author_facet | Mischa Bernasconi Ante Bilic Martin Kauke-Navarro Ali-Farid Safi Ali-Farid Safi |
| author_sort | Mischa Bernasconi |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is a complex disease with a high potential for lymph node metastasis and poor survival rates. Accurate nodal staging is crucial for prognostic assessment and treatment planning in OSCC. Recent research has suggested that nodal tumor volume (NTV) may be a more accurate indicator of nodal disease burden than traditional staging methods. However, the prognostic significance of NTV in OSCC remains unclear. This systematic review aims to evaluate the existing evidence on the relationship between NTV and prognosis in OSCC. A comprehensive search of electronic databases was conducted, and studies meeting inclusion criteria were critically appraised and synthesized. Our review identified 23 studies that investigated the prognostic significance of NTV in OSCC. The majority of studies reported that larger NTV was associated with poorer survival outcomes, although the strength of the association varied. The review also identified several areas for future research, including the standardization of NTV measurement and the integration of NTV into the broader landscape of OSCC management. In conclusion, our review suggests that NTV holds promise as a novel prognostic factor in OSCC, but more research is needed to fully elucidate its potential and inform clinical decision-making. |
| first_indexed | 2024-03-12T14:33:00Z |
| format | Article |
| id | doaj.art-19d2f64aad50438a90882caff2d63d1f |
| institution | Directory Open Access Journal |
| issn | 2673-4842 |
| language | English |
| last_indexed | 2024-03-12T14:33:00Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj.art-19d2f64aad50438a90882caff2d63d1f2023-08-17T12:24:19ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422023-08-01410.3389/froh.2023.12299311229931Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic reviewMischa Bernasconi0Ante Bilic1Martin Kauke-Navarro2Ali-Farid Safi3Ali-Farid Safi4Faculty of Medicine, University of Berne, Berne, SwitzerlandFaculty of Medicine, University of Berne, Berne, SwitzerlandDivision of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United StatesFaculty of Medicine, University of Berne, Berne, SwitzerlandCraniologicum, Center for Craniomaxillofacial Surgery, Berne, SwitzerlandOral squamous cell carcinoma (OSCC) is a complex disease with a high potential for lymph node metastasis and poor survival rates. Accurate nodal staging is crucial for prognostic assessment and treatment planning in OSCC. Recent research has suggested that nodal tumor volume (NTV) may be a more accurate indicator of nodal disease burden than traditional staging methods. However, the prognostic significance of NTV in OSCC remains unclear. This systematic review aims to evaluate the existing evidence on the relationship between NTV and prognosis in OSCC. A comprehensive search of electronic databases was conducted, and studies meeting inclusion criteria were critically appraised and synthesized. Our review identified 23 studies that investigated the prognostic significance of NTV in OSCC. The majority of studies reported that larger NTV was associated with poorer survival outcomes, although the strength of the association varied. The review also identified several areas for future research, including the standardization of NTV measurement and the integration of NTV into the broader landscape of OSCC management. In conclusion, our review suggests that NTV holds promise as a novel prognostic factor in OSCC, but more research is needed to fully elucidate its potential and inform clinical decision-making.https://www.frontiersin.org/articles/10.3389/froh.2023.1229931/fulloral squamous cell carcinomalymph nodevolumeprognostic factornodal metastasis |
| spellingShingle | Mischa Bernasconi Ante Bilic Martin Kauke-Navarro Ali-Farid Safi Ali-Farid Safi Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review Frontiers in Oral Health oral squamous cell carcinoma lymph node volume prognostic factor nodal metastasis |
| title | Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review |
| title_full | Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review |
| title_fullStr | Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review |
| title_full_unstemmed | Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review |
| title_short | Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review |
| title_sort | nodal tumor volume as a prognostic factor for oral squamous cell carcinoma a systematic review |
| topic | oral squamous cell carcinoma lymph node volume prognostic factor nodal metastasis |
| url | https://www.frontiersin.org/articles/10.3389/froh.2023.1229931/full |
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