Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors

Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors

Abstract Background Neuroinflammation in the nucleus accumbens (NAc) is well known to influence the progression of depression. However, the molecular mechanisms triggering NAc neuroinflammation in depression have not been fully elucidated. Progranulin (PGRN) is a multifunctional growth factor that i...

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Bibliographic Details
Main Authors: Jing Wang, Simin Lai, Ting Zhou, Zhihao Xia, Weina Li, Wenqi Sha, Jingjie Liu, Yanjiong Chen
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Progranulin
NAc neuroinflammation
Neuroplasticity
p38 and NF-κB pathways
FTD-like behaviors
Depressive-like behaviors
Online Access:https://doi.org/10.1186/s12974-022-02684-8

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