The CAR–mRNA Interaction Surface Is a Zipper Extension of the Ribosome A Site

The CAR–mRNA Interaction Surface Is a Zipper Extension of the Ribosome A Site

The ribosome CAR interaction surface behaves as an extension of the decoding center A site and has H-bond interactions with the +1 codon, which is next in line to enter the A site. Through molecular dynamic simulations, we investigated the codon sequence specificity of this CAR–mRNA interaction and...

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Bibliographic Details
Main Authors: Carol Dalgarno, Kristen Scopino, Mitsu Raval, Clara Nachmanoff, Eric D. Sakkas, Daniel Krizanc, Kelly M. Thayer, Michael P. Weir
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
ribosome translocation
molecular dynamics
CAR interaction surface
A-site decoding center
ribosome substates
Online Access:https://www.mdpi.com/1422-0067/23/3/1417

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