C1q and central nervous system disorders
C1q is a crucial component of the complement system, which is activated through the classical pathway to perform non-specific immune functions, serving as the first line of defense against pathogens. C1q can also bind to specific receptors to carry out immune and other functions, playing a vital rol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145649/full |
| _version_ | 1797862015897698304 |
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| author | Wenjie Zhang Wenjie Zhang Yuan Chen Hui Pei |
| author_facet | Wenjie Zhang Wenjie Zhang Yuan Chen Hui Pei |
| author_sort | Wenjie Zhang |
| collection | DOAJ |
| description | C1q is a crucial component of the complement system, which is activated through the classical pathway to perform non-specific immune functions, serving as the first line of defense against pathogens. C1q can also bind to specific receptors to carry out immune and other functions, playing a vital role in maintaining immune homeostasis and normal physiological functions. In the developing central nervous system (CNS), C1q functions in synapse formation and pruning, serving as a key player in the development and homeostasis of neuronal networks in the CNS. C1q has a close relationship with microglia and astrocytes, and under their influence, C1q may contribute to the development of CNS disorders. Furthermore, C1q can also have independent effects on neurological disorders, producing either beneficial or detrimental outcomes. Most of the evidence for these functions comes from animal models, with some also from human specimen studies. C1q is now emerging as a promising target for the treatment of a variety of diseases, and clinical trials are already underway for CNS disorders. This article highlights the role of C1q in CNS diseases, offering new directions for the diagnosis and treatment of these conditions. |
| first_indexed | 2024-04-09T22:13:34Z |
| format | Article |
| id | doaj.art-19d45b15a14c4bd8b54e8dca887761d0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T22:13:34Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-19d45b15a14c4bd8b54e8dca887761d02023-03-23T05:54:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11456491145649C1q and central nervous system disordersWenjie Zhang0Wenjie Zhang1Yuan Chen2Hui Pei3Department of Emergency Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of General Practice, Xingyang Sishui Central Health Center, Zhengzhou, ChinaDepartment of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Emergency Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaC1q is a crucial component of the complement system, which is activated through the classical pathway to perform non-specific immune functions, serving as the first line of defense against pathogens. C1q can also bind to specific receptors to carry out immune and other functions, playing a vital role in maintaining immune homeostasis and normal physiological functions. In the developing central nervous system (CNS), C1q functions in synapse formation and pruning, serving as a key player in the development and homeostasis of neuronal networks in the CNS. C1q has a close relationship with microglia and astrocytes, and under their influence, C1q may contribute to the development of CNS disorders. Furthermore, C1q can also have independent effects on neurological disorders, producing either beneficial or detrimental outcomes. Most of the evidence for these functions comes from animal models, with some also from human specimen studies. C1q is now emerging as a promising target for the treatment of a variety of diseases, and clinical trials are already underway for CNS disorders. This article highlights the role of C1q in CNS diseases, offering new directions for the diagnosis and treatment of these conditions.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145649/fullc1qcentral nervous systemneurodevelopmentdegenerative diseasesinflammatory diseasesglioma |
| spellingShingle | Wenjie Zhang Wenjie Zhang Yuan Chen Hui Pei C1q and central nervous system disorders Frontiers in Immunology c1q central nervous system neurodevelopment degenerative diseases inflammatory diseases glioma |
| title | C1q and central nervous system disorders |
| title_full | C1q and central nervous system disorders |
| title_fullStr | C1q and central nervous system disorders |
| title_full_unstemmed | C1q and central nervous system disorders |
| title_short | C1q and central nervous system disorders |
| title_sort | c1q and central nervous system disorders |
| topic | c1q central nervous system neurodevelopment degenerative diseases inflammatory diseases glioma |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145649/full |
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