The p53/Adipose-Tissue/Cancer Nexus
Obesity and the resultant metabolic complications have been associated with an increased risk of cancer. In addition to the systemic metabolic disturbances in obesity that are associated with cancer initiation and progression, the presence of adipose tissue in the tumor microenvironment (TME) contri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00457/full |
| _version_ | 1818945072066985984 |
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| author | Kevin Zwezdaryk Deborah Sullivan Zubaida Saifudeen |
| author_facet | Kevin Zwezdaryk Deborah Sullivan Zubaida Saifudeen |
| author_sort | Kevin Zwezdaryk |
| collection | DOAJ |
| description | Obesity and the resultant metabolic complications have been associated with an increased risk of cancer. In addition to the systemic metabolic disturbances in obesity that are associated with cancer initiation and progression, the presence of adipose tissue in the tumor microenvironment (TME) contributes significantly to malignancy through direct cell-cell interaction or paracrine signaling. This chronic inflammatory state can be maintained by p53-associated mechanisms. Increased p53 levels that are observed in obesity exacerbate the release of inflammatory cytokines that fuel cancer initiation and progression. Dysregulated adipose tissue signaling from the TME can reprogram tumor cell metabolism. The links between p53, cellular metabolism and adipose tissue dysfunction and how they relate to cancer, will be presented in this review. |
| first_indexed | 2024-12-20T07:53:18Z |
| format | Article |
| id | doaj.art-19d5ad628f614df095271c2478f9a069 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T07:53:18Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-19d5ad628f614df095271c2478f9a0692022-12-21T19:47:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-08-01910.3389/fendo.2018.00457376186The p53/Adipose-Tissue/Cancer NexusKevin Zwezdaryk0Deborah Sullivan1Zubaida Saifudeen2Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, United StatesDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, United StatesDepartment of Pediatrics, Section of Nephrology, Tulane University School of Medicine, New Orleans, LA, United StatesObesity and the resultant metabolic complications have been associated with an increased risk of cancer. In addition to the systemic metabolic disturbances in obesity that are associated with cancer initiation and progression, the presence of adipose tissue in the tumor microenvironment (TME) contributes significantly to malignancy through direct cell-cell interaction or paracrine signaling. This chronic inflammatory state can be maintained by p53-associated mechanisms. Increased p53 levels that are observed in obesity exacerbate the release of inflammatory cytokines that fuel cancer initiation and progression. Dysregulated adipose tissue signaling from the TME can reprogram tumor cell metabolism. The links between p53, cellular metabolism and adipose tissue dysfunction and how they relate to cancer, will be presented in this review.https://www.frontiersin.org/article/10.3389/fendo.2018.00457/fullp53adipokinesobesitycancerwhite adipose tissuemetabolism |
| spellingShingle | Kevin Zwezdaryk Deborah Sullivan Zubaida Saifudeen The p53/Adipose-Tissue/Cancer Nexus Frontiers in Endocrinology p53 adipokines obesity cancer white adipose tissue metabolism |
| title | The p53/Adipose-Tissue/Cancer Nexus |
| title_full | The p53/Adipose-Tissue/Cancer Nexus |
| title_fullStr | The p53/Adipose-Tissue/Cancer Nexus |
| title_full_unstemmed | The p53/Adipose-Tissue/Cancer Nexus |
| title_short | The p53/Adipose-Tissue/Cancer Nexus |
| title_sort | p53 adipose tissue cancer nexus |
| topic | p53 adipokines obesity cancer white adipose tissue metabolism |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00457/full |
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