Hemostatic System in Chronic Viral Hepatitis
Hemostasis is balanced by pro- and anticoagulant and pro- and antifibrinolytic factors, most of these being synthesized by the liver. Advanced liver disease is associated with perturbations in the level of these factors due to secretory deficiencies. Thrombocytopenia, reduced levels of factor II-VII...
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2018-06-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://ijbm.org/articles/IJBM_8(2)_RA2.pdf |
| _version_ | 1818499916398329856 |
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| author | Natalia Borisova Yulia Popova Snezhana Sleptsova Vera Yadrikhinskaya Iraida Bilyukina |
| author_facet | Natalia Borisova Yulia Popova Snezhana Sleptsova Vera Yadrikhinskaya Iraida Bilyukina |
| author_sort | Natalia Borisova |
| collection | DOAJ |
| description | Hemostasis is balanced by pro- and anticoagulant and pro- and antifibrinolytic factors, most of these being synthesized by the liver. Advanced liver disease is associated with perturbations in the level of these factors due to secretory deficiencies. Thrombocytopenia, reduced levels of factor II-VII-X, and anti-fibrinolytic factors are all features of CHC infection, suggesting hypocoagulability. However, higher concentrations of VWF and factor VIII, as well as lower concentrations of anticoagulant factors including protein C and S, have also been reported in CHC infections, suggesting hypercoagulability. Thus, the hemostatic balance in the patient with liver disease is relatively unstable as evidenced by the occurrence of both bleeding and thrombotic complications in a significant proportion of patients with chronic viral hepatitis.
In patients with chronic liver disease (CLD), in whom extremely complex alterations of hemostasis occur, one cannot rely on levels of individual coagulation factors, or on simplified tests of hemostasis such as the PT or APTT to predict the hemostatic status. To determine the hemostatic status in these patients, more complex tests and a more comprehensive overview of the hemostatic changes are required. In connection with the latest studies, a revision of the methods for correction of hemostatic system disorders in patients with acute and chronic liver diseases becomes urgent. |
| first_indexed | 2024-12-10T20:36:06Z |
| format | Article |
| id | doaj.art-19d74b75c0154fb89cb00c9d3f48ac58 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-10T20:36:06Z |
| publishDate | 2018-06-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-19d74b75c0154fb89cb00c9d3f48ac582022-12-22T01:34:31ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292018-06-018210210710.21103/Article8(2)_RA2Hemostatic System in Chronic Viral HepatitisNatalia Borisova0Yulia Popova1Snezhana Sleptsova2Vera Yadrikhinskaya3Iraida Bilyukina 4M. K. Ammosov North-Eastern Federal University, Yakutsk, the Republic of Sakha (Yakutia), RussiaM. K. Ammosov North-Eastern Federal University, Yakutsk, the Republic of Sakha (Yakutia), RussiaM. K. Ammosov North-Eastern Federal University, Yakutsk, the Republic of Sakha (Yakutia), RussiaM. K. Ammosov North-Eastern Federal University, Yakutsk, the Republic of Sakha (Yakutia), RussiaM. K. Ammosov North-Eastern Federal University, Yakutsk, the Republic of Sakha (Yakutia), RussiaHemostasis is balanced by pro- and anticoagulant and pro- and antifibrinolytic factors, most of these being synthesized by the liver. Advanced liver disease is associated with perturbations in the level of these factors due to secretory deficiencies. Thrombocytopenia, reduced levels of factor II-VII-X, and anti-fibrinolytic factors are all features of CHC infection, suggesting hypocoagulability. However, higher concentrations of VWF and factor VIII, as well as lower concentrations of anticoagulant factors including protein C and S, have also been reported in CHC infections, suggesting hypercoagulability. Thus, the hemostatic balance in the patient with liver disease is relatively unstable as evidenced by the occurrence of both bleeding and thrombotic complications in a significant proportion of patients with chronic viral hepatitis. In patients with chronic liver disease (CLD), in whom extremely complex alterations of hemostasis occur, one cannot rely on levels of individual coagulation factors, or on simplified tests of hemostasis such as the PT or APTT to predict the hemostatic status. To determine the hemostatic status in these patients, more complex tests and a more comprehensive overview of the hemostatic changes are required. In connection with the latest studies, a revision of the methods for correction of hemostatic system disorders in patients with acute and chronic liver diseases becomes urgent.http://ijbm.org/articles/IJBM_8(2)_RA2.pdfhemostasischronic viral hepatitisliver diseasesthrombocytopeniathrombosisbleedingcoagulopathy |
| spellingShingle | Natalia Borisova Yulia Popova Snezhana Sleptsova Vera Yadrikhinskaya Iraida Bilyukina Hemostatic System in Chronic Viral Hepatitis International Journal of Biomedicine hemostasis chronic viral hepatitis liver diseases thrombocytopenia thrombosis bleeding coagulopathy |
| title | Hemostatic System in Chronic Viral Hepatitis |
| title_full | Hemostatic System in Chronic Viral Hepatitis |
| title_fullStr | Hemostatic System in Chronic Viral Hepatitis |
| title_full_unstemmed | Hemostatic System in Chronic Viral Hepatitis |
| title_short | Hemostatic System in Chronic Viral Hepatitis |
| title_sort | hemostatic system in chronic viral hepatitis |
| topic | hemostasis chronic viral hepatitis liver diseases thrombocytopenia thrombosis bleeding coagulopathy |
| url | http://ijbm.org/articles/IJBM_8(2)_RA2.pdf |
| work_keys_str_mv | AT nataliaborisova hemostaticsysteminchronicviralhepatitis AT yuliapopova hemostaticsysteminchronicviralhepatitis AT snezhanasleptsova hemostaticsysteminchronicviralhepatitis AT verayadrikhinskaya hemostaticsysteminchronicviralhepatitis AT iraidabilyukina hemostaticsysteminchronicviralhepatitis |