Role of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini review
Abstract The word of hemoglobinopathy is described for an array of disorders that affecting hemoglobin (Hb) functions. Hb is a molecule with 68 kDa molecular weight, serving as oxygen carrying metalloprotein. Hemoglobinopathy includes a wide range of Hb structural deficits varying from thalassemia t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40164-019-0145-x |
| _version_ | 1828525137498996736 |
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| author | Zahra Mousavi Zinat Yazdani Alireza Moradabadi Fatemeh Hoseinpourkasgari Gholamhossein Hassanshahi |
| author_facet | Zahra Mousavi Zinat Yazdani Alireza Moradabadi Fatemeh Hoseinpourkasgari Gholamhossein Hassanshahi |
| author_sort | Zahra Mousavi |
| collection | DOAJ |
| description | Abstract The word of hemoglobinopathy is described for an array of disorders that affecting hemoglobin (Hb) functions. Hb is a molecule with 68 kDa molecular weight, serving as oxygen carrying metalloprotein. Hemoglobinopathy includes a wide range of Hb structural deficits varying from thalassemia to sickle cell disease. Cyto-chemokine network members are pivotally involved in the pathogenesis of hemoglobinopathies, however, the exact role of these mediators in the development of these disorders yet to be well addressed. Cytokines and chemokines are generated by inflamed endothelial cells that promote the expression of their respected receptors and further activate NF-κβ, recruit red blood cells (RBCs) and white blood cells (WBCs) toward the inflamed endothelium. Therefore, due to critical roles played by the cyto-chemokine network in several aspects of hemoglobinopathies pathophysiology including apoptosis of endothelial cells, RBC, WBC and etc.…, in the present review, we focused on the critical parts played by this network in the pathogenesis of hemoglobinopathies. |
| first_indexed | 2024-12-11T21:00:21Z |
| format | Article |
| id | doaj.art-19d7f07cc0b1426cb7df1326822e38cb |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-12-11T21:00:21Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-19d7f07cc0b1426cb7df1326822e38cb2022-12-22T00:50:59ZengBMCExperimental Hematology & Oncology2162-36192019-09-01811610.1186/s40164-019-0145-xRole of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini reviewZahra Mousavi0Zinat Yazdani1Alireza Moradabadi2Fatemeh Hoseinpourkasgari3Gholamhossein Hassanshahi4Department of Hematology and Medical Laboratory Sciences, Iranshahr University of Medical SciencesDepartment of Hematology and Blood Banking, Kerman University of Medical SciencesDepartment of Hematology, School of Paramedicine, Arak University of Medical ScienceDepartment of Hematology and Blood Banking, Kerman University of Medical SciencesMolecular Medicine Research Center, Rafsanjan University of Medical SciencesAbstract The word of hemoglobinopathy is described for an array of disorders that affecting hemoglobin (Hb) functions. Hb is a molecule with 68 kDa molecular weight, serving as oxygen carrying metalloprotein. Hemoglobinopathy includes a wide range of Hb structural deficits varying from thalassemia to sickle cell disease. Cyto-chemokine network members are pivotally involved in the pathogenesis of hemoglobinopathies, however, the exact role of these mediators in the development of these disorders yet to be well addressed. Cytokines and chemokines are generated by inflamed endothelial cells that promote the expression of their respected receptors and further activate NF-κβ, recruit red blood cells (RBCs) and white blood cells (WBCs) toward the inflamed endothelium. Therefore, due to critical roles played by the cyto-chemokine network in several aspects of hemoglobinopathies pathophysiology including apoptosis of endothelial cells, RBC, WBC and etc.…, in the present review, we focused on the critical parts played by this network in the pathogenesis of hemoglobinopathies.http://link.springer.com/article/10.1186/s40164-019-0145-xHemoglobinopathySickle-cell disease (SCD)CytokineChemokine |
| spellingShingle | Zahra Mousavi Zinat Yazdani Alireza Moradabadi Fatemeh Hoseinpourkasgari Gholamhossein Hassanshahi Role of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini review Experimental Hematology & Oncology Hemoglobinopathy Sickle-cell disease (SCD) Cytokine Chemokine |
| title | Role of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini review |
| title_full | Role of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini review |
| title_fullStr | Role of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini review |
| title_full_unstemmed | Role of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini review |
| title_short | Role of some members of chemokine/cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies: a mini review |
| title_sort | role of some members of chemokine cytokine network in the pathogenesis of thalassemia and sickle cell hemoglobinopathies a mini review |
| topic | Hemoglobinopathy Sickle-cell disease (SCD) Cytokine Chemokine |
| url | http://link.springer.com/article/10.1186/s40164-019-0145-x |
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