Folic Acid–Functionalized Metal-Organic Framework Nanoparticles as Drug Carriers Improved Bufalin Antitumor Activity Against Breast Cancer

Folic Acid–Functionalized Metal-Organic Framework Nanoparticles as Drug Carriers Improved Bufalin Antitumor Activity Against Breast Cancer

Bufalin (Buf), an active ingredient of the traditional Chinese medicine Chansu, is known to have anticancer effects for breast cancer. However, its poor solubility, high toxicity, and extensive side effects limit its use. Metal-organic frameworks (MOFs) are a class of promising drug delivery systems...

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Bibliographic Details
Main Authors: Hairong Zeng, Chao Xia, Bei Zhao, Mengmeng Zhu, HaoYue Zhang, Die Zhang, Xin Rui, Huili Li, Yi Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
bufalin
MOF
breast cancer
drug delivery
antitumor
tumor targeting
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.747992/full

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