Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i>
Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult <i>Drosophila melanogaste...
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MDPI AG
2023-04-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/4/635 |
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| author | Helgi B. Schiöth Laura Donzelli Nicklas Arvidsson Michael J. Williams Thiago C. Moulin |
| author_facet | Helgi B. Schiöth Laura Donzelli Nicklas Arvidsson Michael J. Williams Thiago C. Moulin |
| author_sort | Helgi B. Schiöth |
| collection | DOAJ |
| description | Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult <i>Drosophila melanogaster</i>. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in <i>Drosophila</i> can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be affected by MK-801. Given the versatility of <i>Drosophila</i> as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI. |
| first_indexed | 2024-03-11T05:12:44Z |
| format | Article |
| id | doaj.art-19d8df7e7992494bb6076b232a7c273e |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T05:12:44Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-19d8df7e7992494bb6076b232a7c273e2023-11-17T18:25:01ZengMDPI AGBiology2079-77372023-04-0112463510.3390/biology12040635Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i>Helgi B. Schiöth0Laura Donzelli1Nicklas Arvidsson2Michael J. Williams3Thiago C. Moulin4Department of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, SwedenDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, SwedenDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, SwedenDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, SwedenDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, SwedenPrepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. PPI has been observed across various vertebrate and invertebrate species; however, it has not yet been reported in adult <i>Drosophila melanogaster</i>. In this study, we describe the first detection of PPI of visually evoked locomotor arousal in flies. To validate our findings, we demonstrate that PPI in <i>Drosophila</i> can be partially reverted by the N-methyl D-aspartate (NMDA) receptor antagonist MK-801, known for inducing sensorimotor gating deficits in rodent models. Additionally, we show that the visually evoked response can be inhibited by multiple stimuli presentation, which can also be affected by MK-801. Given the versatility of <i>Drosophila</i> as a model organism for genetic screening and analysis, our results suggest that high-throughput behavioral screenings of adult flies can become a valuable tool for investigating the mechanisms behind PPI.https://www.mdpi.com/2079-7737/12/4/635prepulse inhibition (PPI)<i>Drosophila melanogaster</i>escape responsestartleanxietyschizophrenia |
| spellingShingle | Helgi B. Schiöth Laura Donzelli Nicklas Arvidsson Michael J. Williams Thiago C. Moulin Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i> Biology prepulse inhibition (PPI) <i>Drosophila melanogaster</i> escape response startle anxiety schizophrenia |
| title | Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i> |
| title_full | Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i> |
| title_fullStr | Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i> |
| title_full_unstemmed | Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i> |
| title_short | Evidence for Prepulse Inhibition of Visually Evoked Motor Response in <i>Drosophila melanogaster</i> |
| title_sort | evidence for prepulse inhibition of visually evoked motor response in i drosophila melanogaster i |
| topic | prepulse inhibition (PPI) <i>Drosophila melanogaster</i> escape response startle anxiety schizophrenia |
| url | https://www.mdpi.com/2079-7737/12/4/635 |
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