Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, bucca...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1303974/full |
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| author | Annemarie J. Carver Annemarie J. Carver Annemarie J. Carver Benjamin Hing Benjamin Hing Benjamin A. Elser Benjamin A. Elser Benjamin A. Elser Stephanie J. Lussier Stephanie J. Lussier Stephanie J. Lussier Takehiko Yamanashi Takehiko Yamanashi Takehiko Yamanashi Takehiko Yamanashi Matthew A. Howard Matthew A. Howard Hiroto Kawasaki Hiroto Kawasaki Gen Shinozaki Gen Shinozaki Gen Shinozaki Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens |
| author_facet | Annemarie J. Carver Annemarie J. Carver Annemarie J. Carver Benjamin Hing Benjamin Hing Benjamin A. Elser Benjamin A. Elser Benjamin A. Elser Stephanie J. Lussier Stephanie J. Lussier Stephanie J. Lussier Takehiko Yamanashi Takehiko Yamanashi Takehiko Yamanashi Takehiko Yamanashi Matthew A. Howard Matthew A. Howard Hiroto Kawasaki Hiroto Kawasaki Gen Shinozaki Gen Shinozaki Gen Shinozaki Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens |
| author_sort | Annemarie J. Carver |
| collection | DOAJ |
| description | Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing neurosurgery (n = 35) for intractable epilepsy. DNA was isolated from samples and average telomere length assessed by qPCR. Correlations of telomere length between tissue samples were calculated across subjects. When data were stratified by sex, saliva telomere length correlated with brain telomere length in males only. Buccal telomere length correlated with brain telomere length when males and females were combined. These findings indicate that in living subjects, telomere length in peripheral tissues variably correlates with that in brain and may be dependent on sex. Peripheral tissue telomere length may provide insight into brain telomere length, relevant to assessment of brain disorder pathophysiology. |
| first_indexed | 2024-03-07T14:02:43Z |
| format | Article |
| id | doaj.art-19d94e5cb6824f309c2923260b1a6dd5 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-07T14:02:43Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-19d94e5cb6824f309c2923260b1a6dd52024-03-07T04:38:38ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992024-03-011710.3389/fnmol.2024.13039741303974Correlation of telomere length in brain tissue with peripheral tissues in living human subjectsAnnemarie J. Carver0Annemarie J. Carver1Annemarie J. Carver2Benjamin Hing3Benjamin Hing4Benjamin A. Elser5Benjamin A. Elser6Benjamin A. Elser7Stephanie J. Lussier8Stephanie J. Lussier9Stephanie J. Lussier10Takehiko Yamanashi11Takehiko Yamanashi12Takehiko Yamanashi13Takehiko Yamanashi14Matthew A. Howard15Matthew A. Howard16Hiroto Kawasaki17Hiroto Kawasaki18Gen Shinozaki19Gen Shinozaki20Gen Shinozaki21Hanna E. Stevens22Hanna E. Stevens23Hanna E. Stevens24Hanna E. Stevens25Hanna E. Stevens26Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, United StatesDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesInterdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, United StatesDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesBiostatistics Graduate Program, College of Public Health, University of Iowa, Iowa City, IA, United StatesDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Standford University, Stanford, CA, United StatesDivision of Neuropsychiatry, Tottori University, Tottori, JapanIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Standford University, Stanford, CA, United StatesDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesIowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesInterdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, United StatesInterdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, United StatesHawk-Intellectual and Developmental Disabilities Research Center, University of Iowa, Iowa City, IA, United StatesTelomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing neurosurgery (n = 35) for intractable epilepsy. DNA was isolated from samples and average telomere length assessed by qPCR. Correlations of telomere length between tissue samples were calculated across subjects. When data were stratified by sex, saliva telomere length correlated with brain telomere length in males only. Buccal telomere length correlated with brain telomere length when males and females were combined. These findings indicate that in living subjects, telomere length in peripheral tissues variably correlates with that in brain and may be dependent on sex. Peripheral tissue telomere length may provide insight into brain telomere length, relevant to assessment of brain disorder pathophysiology.https://www.frontiersin.org/articles/10.3389/fnmol.2024.1303974/fullbrainbloodbuccal tissuesalivatelomereneuroscience |
| spellingShingle | Annemarie J. Carver Annemarie J. Carver Annemarie J. Carver Benjamin Hing Benjamin Hing Benjamin A. Elser Benjamin A. Elser Benjamin A. Elser Stephanie J. Lussier Stephanie J. Lussier Stephanie J. Lussier Takehiko Yamanashi Takehiko Yamanashi Takehiko Yamanashi Takehiko Yamanashi Matthew A. Howard Matthew A. Howard Hiroto Kawasaki Hiroto Kawasaki Gen Shinozaki Gen Shinozaki Gen Shinozaki Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens Hanna E. Stevens Correlation of telomere length in brain tissue with peripheral tissues in living human subjects Frontiers in Molecular Neuroscience brain blood buccal tissue saliva telomere neuroscience |
| title | Correlation of telomere length in brain tissue with peripheral tissues in living human subjects |
| title_full | Correlation of telomere length in brain tissue with peripheral tissues in living human subjects |
| title_fullStr | Correlation of telomere length in brain tissue with peripheral tissues in living human subjects |
| title_full_unstemmed | Correlation of telomere length in brain tissue with peripheral tissues in living human subjects |
| title_short | Correlation of telomere length in brain tissue with peripheral tissues in living human subjects |
| title_sort | correlation of telomere length in brain tissue with peripheral tissues in living human subjects |
| topic | brain blood buccal tissue saliva telomere neuroscience |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1303974/full |
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