The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study
Abstract Purpose This study investigated and compared the effects of Gd enhancement on brain tumours with a half-dose of contrast medium at 5.0 T and with a full dose at 3.0 T. Methods Twelve subjects diagnosed with brain tumours were included in this study and underwent MRI after contrast agent inj...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-024-01270-z |
| _version_ | 1797208974016118784 |
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| author | Zhiyong Jiang Wenbo Sun Dan Xu Hao Mei Jianmin Yuan Xiaopeng Song Chao Ma Haibo Xu |
| author_facet | Zhiyong Jiang Wenbo Sun Dan Xu Hao Mei Jianmin Yuan Xiaopeng Song Chao Ma Haibo Xu |
| author_sort | Zhiyong Jiang |
| collection | DOAJ |
| description | Abstract Purpose This study investigated and compared the effects of Gd enhancement on brain tumours with a half-dose of contrast medium at 5.0 T and with a full dose at 3.0 T. Methods Twelve subjects diagnosed with brain tumours were included in this study and underwent MRI after contrast agent injection at 3.0 T (full dose) or 5.0 T (half dose) with a 3D T1-weighted gradient echo sequence. The postcontrast images were compared by two independent neuroradiologists in terms of the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and subjective image quality score on a ten-point Likert scale. Quantitative indices and subjective quality ratings were compared with paired Student's t tests, and interreader agreement was assessed with the intraclass correlation coefficient (ICC). Results A total of 16 enhanced tumour lesions were detected. The SNR was significantly greater at 5.0 T than at 3.0 T in grey matter, white matter and enhanced lesions (p < 0.001). The CNR was also significantly greater at 5.0 T than at 3.0 T for grey matter/tumour lesions, white matter/tumour lesions, and grey matter/white matter (p < 0.001). Subjective evaluation revealed that the internal structure and outline of the tumour lesions were more clearly displayed with a half-dose at 5.0 T (Likert scale 8.1 ± 0.3 at 3.0 T, 8.9 ± 0.3 at 5.0 T, p < 0.001), and the effects of enhancement in the lesions were comparable to those with a full dose at 3.0 T (7.8 ± 0.3 at 3.0 T, 8.7 ± 0.4 at 5.0 T, p < 0.001). All subjective scores were good to excellent at both 5.0 T and 3.0 T. Conclusion Both quantitative and subjective evaluation parameters suggested that half-dose enhanced scanning via 5.0 T MRI might be feasible for meeting clinical diagnostic requirements, as the image quality remains optimal. Enhanced scanning at 5.0 T with a half-dose of contrast agents might benefit patients with conditions that require less intravenous contrast agent, such as renal dysfunction. |
| first_indexed | 2024-04-24T09:47:19Z |
| format | Article |
| id | doaj.art-19db09902ef041578671ede7f2fde68e |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-04-24T09:47:19Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-19db09902ef041578671ede7f2fde68e2024-04-14T11:32:48ZengBMCBMC Medical Imaging1471-23422024-04-0124111110.1186/s12880-024-01270-zThe feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary studyZhiyong Jiang0Wenbo Sun1Dan Xu2Hao Mei3Jianmin Yuan4Xiaopeng Song5Chao Ma6Haibo Xu7Department of Radiology, Zhongnan Hospital of Wuhan UniversityDepartment of Radiology, Zhongnan Hospital of Wuhan UniversityDepartment of Nuclear Medicine, Zhongnan Hospital of Wuhan UniversityDepartment of Radiology, Zhongnan Hospital of Wuhan UniversityUnited Imaging HealthcareUnited Imaging HealthcareDepartment of Neurosurgery, Zhongnan HospitalDepartment of Radiology, Zhongnan Hospital of Wuhan UniversityAbstract Purpose This study investigated and compared the effects of Gd enhancement on brain tumours with a half-dose of contrast medium at 5.0 T and with a full dose at 3.0 T. Methods Twelve subjects diagnosed with brain tumours were included in this study and underwent MRI after contrast agent injection at 3.0 T (full dose) or 5.0 T (half dose) with a 3D T1-weighted gradient echo sequence. The postcontrast images were compared by two independent neuroradiologists in terms of the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and subjective image quality score on a ten-point Likert scale. Quantitative indices and subjective quality ratings were compared with paired Student's t tests, and interreader agreement was assessed with the intraclass correlation coefficient (ICC). Results A total of 16 enhanced tumour lesions were detected. The SNR was significantly greater at 5.0 T than at 3.0 T in grey matter, white matter and enhanced lesions (p < 0.001). The CNR was also significantly greater at 5.0 T than at 3.0 T for grey matter/tumour lesions, white matter/tumour lesions, and grey matter/white matter (p < 0.001). Subjective evaluation revealed that the internal structure and outline of the tumour lesions were more clearly displayed with a half-dose at 5.0 T (Likert scale 8.1 ± 0.3 at 3.0 T, 8.9 ± 0.3 at 5.0 T, p < 0.001), and the effects of enhancement in the lesions were comparable to those with a full dose at 3.0 T (7.8 ± 0.3 at 3.0 T, 8.7 ± 0.4 at 5.0 T, p < 0.001). All subjective scores were good to excellent at both 5.0 T and 3.0 T. Conclusion Both quantitative and subjective evaluation parameters suggested that half-dose enhanced scanning via 5.0 T MRI might be feasible for meeting clinical diagnostic requirements, as the image quality remains optimal. Enhanced scanning at 5.0 T with a half-dose of contrast agents might benefit patients with conditions that require less intravenous contrast agent, such as renal dysfunction.https://doi.org/10.1186/s12880-024-01270-z5.0 TMRIHalf-dose contrast agentUltrahigh fieldBrain tumours |
| spellingShingle | Zhiyong Jiang Wenbo Sun Dan Xu Hao Mei Jianmin Yuan Xiaopeng Song Chao Ma Haibo Xu The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study BMC Medical Imaging 5.0 T MRI Half-dose contrast agent Ultrahigh field Brain tumours |
| title | The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study |
| title_full | The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study |
| title_fullStr | The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study |
| title_full_unstemmed | The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study |
| title_short | The feasibility of half-dose contrast-enhanced scanning of brain tumours at 5.0 T: a preliminary study |
| title_sort | feasibility of half dose contrast enhanced scanning of brain tumours at 5 0 t a preliminary study |
| topic | 5.0 T MRI Half-dose contrast agent Ultrahigh field Brain tumours |
| url | https://doi.org/10.1186/s12880-024-01270-z |
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