Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency
Abstract Objective Epidemiological evidence indicated a relationship between vitamin D (VD) and depression with anxiety, but their therapeutic relationship has not been fully elucidated. This study aimed to examine whether VD supplementation would relieve symptoms in patients with depression and anx...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-11-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1760 |
| _version_ | 1818268760609390592 |
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| author | Cuizhen Zhu Yu Zhang Ting Wang Yezhe Lin Jiakuai Yu Qingrong Xia Peng Zhu Dao‐min Zhu |
| author_facet | Cuizhen Zhu Yu Zhang Ting Wang Yezhe Lin Jiakuai Yu Qingrong Xia Peng Zhu Dao‐min Zhu |
| author_sort | Cuizhen Zhu |
| collection | DOAJ |
| description | Abstract Objective Epidemiological evidence indicated a relationship between vitamin D (VD) and depression with anxiety, but their therapeutic relationship has not been fully elucidated. This study aimed to examine whether VD supplementation would relieve symptoms in patients with depression and anxiety with low serum 25‐hydroxy VD [25(OH) D] levels. Method Participants with low 25(OH)D levels were randomized to control or daily VD group and were followed up for 6 months. Serum concentrations of 25(OH) D were measured using commercial kits. Psychological symptoms were evaluated with the Hamilton Depression Rating Scale‐17 (HAMD‐17), Revised Social Anhedonia Scale (RSAS), Revised Physical Anhedonia scale (RPAS), and Hamilton Anxiety Rating Scale‐14 (HAMA‐14). The trial was listed in the trial registration (http://www.medresman.org.cn/uc/index.aspx; NTR number: ChiCTR2000030130). Results In this clinical population, no significant difference in depression symptoms was detected between VD group and control group at both baseline and at the endpoint of our study. The HAMD‐17, RSAS, and RPAS scores did not change significantly between VD and control groups from baseline to endpoint (all p > .05). However, there was a significant difference in time effect of the total HAMA‐14 scores between the two groups (β [95% Cl] = −2.235 [−3.818, −0.653], p = .006). Conclusions Vitamin D supplementation could improve the anxiety symptoms but not depressive symptoms in depressive patients with low VD level after the 6‐month intervention. |
| first_indexed | 2024-12-12T20:43:37Z |
| format | Article |
| id | doaj.art-19db85bb1c03420a8cddaa33d525c8e9 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-12T20:43:37Z |
| publishDate | 2020-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-19db85bb1c03420a8cddaa33d525c8e92022-12-22T00:12:39ZengWileyBrain and Behavior2162-32792020-11-011011n/an/a10.1002/brb3.1760Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiencyCuizhen Zhu0Yu Zhang1Ting Wang2Yezhe Lin3Jiakuai Yu4Qingrong Xia5Peng Zhu6Dao‐min Zhu7Department of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical University Hefei ChinaDepartment of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical University Hefei ChinaDepartment of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical University Hefei ChinaDepartment of Psychiatry University of Rochester Medical Center Rochester NY USADepartment of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical University Hefei ChinaDepartment of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical University Hefei ChinaDepartment of Maternal, Child & Adolescent Health School of Public Health Anhui Medical University Hefei ChinaDepartment of Sleep Disorders Affiliated Psychological Hospital of Anhui Medical University Hefei ChinaAbstract Objective Epidemiological evidence indicated a relationship between vitamin D (VD) and depression with anxiety, but their therapeutic relationship has not been fully elucidated. This study aimed to examine whether VD supplementation would relieve symptoms in patients with depression and anxiety with low serum 25‐hydroxy VD [25(OH) D] levels. Method Participants with low 25(OH)D levels were randomized to control or daily VD group and were followed up for 6 months. Serum concentrations of 25(OH) D were measured using commercial kits. Psychological symptoms were evaluated with the Hamilton Depression Rating Scale‐17 (HAMD‐17), Revised Social Anhedonia Scale (RSAS), Revised Physical Anhedonia scale (RPAS), and Hamilton Anxiety Rating Scale‐14 (HAMA‐14). The trial was listed in the trial registration (http://www.medresman.org.cn/uc/index.aspx; NTR number: ChiCTR2000030130). Results In this clinical population, no significant difference in depression symptoms was detected between VD group and control group at both baseline and at the endpoint of our study. The HAMD‐17, RSAS, and RPAS scores did not change significantly between VD and control groups from baseline to endpoint (all p > .05). However, there was a significant difference in time effect of the total HAMA‐14 scores between the two groups (β [95% Cl] = −2.235 [−3.818, −0.653], p = .006). Conclusions Vitamin D supplementation could improve the anxiety symptoms but not depressive symptoms in depressive patients with low VD level after the 6‐month intervention.https://doi.org/10.1002/brb3.1760anxietydepressionvitamin D deficiencyvitamin D supplementation |
| spellingShingle | Cuizhen Zhu Yu Zhang Ting Wang Yezhe Lin Jiakuai Yu Qingrong Xia Peng Zhu Dao‐min Zhu Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency Brain and Behavior anxiety depression vitamin D deficiency vitamin D supplementation |
| title | Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency |
| title_full | Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency |
| title_fullStr | Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency |
| title_full_unstemmed | Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency |
| title_short | Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency |
| title_sort | vitamin d supplementation improves anxiety but not depression symptoms in patients with vitamin d deficiency |
| topic | anxiety depression vitamin D deficiency vitamin D supplementation |
| url | https://doi.org/10.1002/brb3.1760 |
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