Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review
Abstract Background Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English litera...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12902-019-0449-1 |
| _version_ | 1819172917342109696 |
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| author | Tian Yang Xudan Yang Luping Wang Jun Mo |
| author_facet | Tian Yang Xudan Yang Luping Wang Jun Mo |
| author_sort | Tian Yang |
| collection | DOAJ |
| description | Abstract Background Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English literature. Case presentation We present a case of a patient with ADP accompanied by abdominal pain and diabetic ketoacidosis as the initial clinical presentation. A 30-year-old man presented with a 3-month history of recurrent onset of persistent mild epigastric pain, which worsen when eating. Laboratory tests revealed metabolic acidosis, hyperglycemia, and ketonuria. Phase contrast CT and MRCP showed the absence of the body and tail of the pancreas, as well as the dorsal pancreatic duct. The C-peptide release test indicated β-cell dysfunction. A combination therapy of insulin, pancreatic enzyme supplements, and mosapride citrate were administrated and the pain gradually resolved. Conclusions As glucose metabolism disorders can vary across different individuals, we advise clinicians to consider the diagnosis of ADP for a patient who presents with a glucose metabolism disorder accompanied by abdominal pain, pancreatitis or steatorrhea. |
| first_indexed | 2024-12-22T20:14:48Z |
| format | Article |
| id | doaj.art-19dc32e1db0f46f5b745b2b7d7f292e6 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-22T20:14:48Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-19dc32e1db0f46f5b745b2b7d7f292e62022-12-21T18:13:59ZengBMCBMC Endocrine Disorders1472-68232019-11-011911510.1186/s12902-019-0449-1Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature reviewTian Yang0Xudan Yang1Luping Wang2Jun Mo3Department of Endocrinology, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, 322000Department of Internal Medicine, Jinhua Municipal Central Hospital of, Zhejiang UniversityDepartment of Endocrinology, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, 322000Department of Neurosurgery, Fourth Affiliated Hospital, School of MedicineAbstract Background Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English literature. Case presentation We present a case of a patient with ADP accompanied by abdominal pain and diabetic ketoacidosis as the initial clinical presentation. A 30-year-old man presented with a 3-month history of recurrent onset of persistent mild epigastric pain, which worsen when eating. Laboratory tests revealed metabolic acidosis, hyperglycemia, and ketonuria. Phase contrast CT and MRCP showed the absence of the body and tail of the pancreas, as well as the dorsal pancreatic duct. The C-peptide release test indicated β-cell dysfunction. A combination therapy of insulin, pancreatic enzyme supplements, and mosapride citrate were administrated and the pain gradually resolved. Conclusions As glucose metabolism disorders can vary across different individuals, we advise clinicians to consider the diagnosis of ADP for a patient who presents with a glucose metabolism disorder accompanied by abdominal pain, pancreatitis or steatorrhea.http://link.springer.com/article/10.1186/s12902-019-0449-1Agenesis of the dorsal pancreasDiabetic ketoacidosisDiabetes mellitusC-peptide release test |
| spellingShingle | Tian Yang Xudan Yang Luping Wang Jun Mo Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review BMC Endocrine Disorders Agenesis of the dorsal pancreas Diabetic ketoacidosis Diabetes mellitus C-peptide release test |
| title | Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review |
| title_full | Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review |
| title_fullStr | Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review |
| title_full_unstemmed | Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review |
| title_short | Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review |
| title_sort | agenesis of the dorsal pancreas presenting with diabetic ketoacidosis a case report and literature review |
| topic | Agenesis of the dorsal pancreas Diabetic ketoacidosis Diabetes mellitus C-peptide release test |
| url | http://link.springer.com/article/10.1186/s12902-019-0449-1 |
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