An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulations
A highly sensitive indirect atomic absorption spectrophotometric (AAS) method has been developed for the determination of very low concentrations of ciprofloxacin, amoxycillin and diclofenac sodium. The method is based on the oxidation of these drugs with iron(III). The excess of iron(III) was extra...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2008-05-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/JSCS/Vol73/No5/JSCS-3739.pdf |
| _version_ | 1818937648639639552 |
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| author | MAHMOUD MOHAMED ISSA R’AFAT MAHMOUD NEJEM MONZER AL-KHOLY NASER SAID EL-ABADLA RAFIK SOBHI HELLES AKILA AMIN SALEH |
| author_facet | MAHMOUD MOHAMED ISSA R’AFAT MAHMOUD NEJEM MONZER AL-KHOLY NASER SAID EL-ABADLA RAFIK SOBHI HELLES AKILA AMIN SALEH |
| author_sort | MAHMOUD MOHAMED ISSA |
| collection | DOAJ |
| description | A highly sensitive indirect atomic absorption spectrophotometric (AAS) method has been developed for the determination of very low concentrations of ciprofloxacin, amoxycillin and diclofenac sodium. The method is based on the oxidation of these drugs with iron(III). The excess of iron(III) was extracted into diethyl ether and then the iron(II) in the aqueous layer was aspirated into an air–acetylene flame and determined by AAS. The linear concentration ranges were 25–400, 50–500 and 60–600 ng ml-1 for ciprofloxacin, amoxycillin and diclofenac sodium, respectively. The results were statistically compared with the official method using t- and f-test at p < 0.05. There were insignificant interferences from most of the excipients present. The intra- and inter-day assay coefficients of variation were less than 6.1 % and the recoveries ranged from 95 to 103 %. The method was applied for the analysis of these drug substances in their commercial pharmaceutical formulations. |
| first_indexed | 2024-12-20T05:55:18Z |
| format | Article |
| id | doaj.art-19dd5afbbf6e49039c7c7d9ce0b13f66 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-20T05:55:18Z |
| publishDate | 2008-05-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-19dd5afbbf6e49039c7c7d9ce0b13f662022-12-21T19:51:03ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392008-05-01735569576An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulationsMAHMOUD MOHAMED ISSAR’AFAT MAHMOUD NEJEMMONZER AL-KHOLYNASER SAID EL-ABADLARAFIK SOBHI HELLESAKILA AMIN SALEHA highly sensitive indirect atomic absorption spectrophotometric (AAS) method has been developed for the determination of very low concentrations of ciprofloxacin, amoxycillin and diclofenac sodium. The method is based on the oxidation of these drugs with iron(III). The excess of iron(III) was extracted into diethyl ether and then the iron(II) in the aqueous layer was aspirated into an air–acetylene flame and determined by AAS. The linear concentration ranges were 25–400, 50–500 and 60–600 ng ml-1 for ciprofloxacin, amoxycillin and diclofenac sodium, respectively. The results were statistically compared with the official method using t- and f-test at p < 0.05. There were insignificant interferences from most of the excipients present. The intra- and inter-day assay coefficients of variation were less than 6.1 % and the recoveries ranged from 95 to 103 %. The method was applied for the analysis of these drug substances in their commercial pharmaceutical formulations.http://www.shd.org.yu/JSCS/Vol73/No5/JSCS-3739.pdfciprofloxacinamoxycillindiclofenac sodiumindirect atomic absorption spectrometry |
| spellingShingle | MAHMOUD MOHAMED ISSA R’AFAT MAHMOUD NEJEM MONZER AL-KHOLY NASER SAID EL-ABADLA RAFIK SOBHI HELLES AKILA AMIN SALEH An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulations Journal of the Serbian Chemical Society ciprofloxacin amoxycillin diclofenac sodium indirect atomic absorption spectrometry |
| title | An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulations |
| title_full | An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulations |
| title_fullStr | An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulations |
| title_full_unstemmed | An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulations |
| title_short | An indirect atomic absorption spectrometric determination of ciprofloxacin, amoxycillin and diclofenac sodium in pharmaceutical formulations |
| title_sort | indirect atomic absorption spectrometric determination of ciprofloxacin amoxycillin and diclofenac sodium in pharmaceutical formulations |
| topic | ciprofloxacin amoxycillin diclofenac sodium indirect atomic absorption spectrometry |
| url | http://www.shd.org.yu/JSCS/Vol73/No5/JSCS-3739.pdf |
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