Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions
Subjects suffering from psychosis frequently experience anxiety. However, mechanisms underlying this comorbidity remain still unclear. We investigated whether neurochemical and neuroendocrine dysfunctions were involved in the development of anxiety-like behavior in a rodent model of psychotic-like s...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222015700 |
| _version_ | 1811177259954864128 |
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| author | Stefania Dimonte Vladyslav Sikora Maria Bove Maria Grazia Morgese Paolo Tucci Stefania Schiavone Luigia Trabace |
| author_facet | Stefania Dimonte Vladyslav Sikora Maria Bove Maria Grazia Morgese Paolo Tucci Stefania Schiavone Luigia Trabace |
| author_sort | Stefania Dimonte |
| collection | DOAJ |
| description | Subjects suffering from psychosis frequently experience anxiety. However, mechanisms underlying this comorbidity remain still unclear. We investigated whether neurochemical and neuroendocrine dysfunctions were involved in the development of anxiety-like behavior in a rodent model of psychotic-like symptoms, obtained by exposing male rats to social isolation rearing from postnatal day 21 to postnatal day 70. In the elevated zero maze test, isolated rats showed a significant reduction in the time spent in the open arms, as well as an increase in the time spent in the closed arms, compared to controls. An increased grooming time in the open field test was also observed in isolated animals. Isolation-induced anxiety-like behavior was accompanied by a decrease of plasmatic oxytocin, prolactin, ghrelin and melatonin levels, whereas plasmatic amount of Neuropeptide S was not altered. Social isolation also caused a reduction of noradrenaline, serotonin and GABA levels, together with an increase of serotonin turnover and glutamate levels in the amygdala of isolated animals. No significant differences were found in noradrenaline and serotonin levels, as well as in serotonin turnover in hippocampus, while glutamate amount was increased and GABA levels were reduced in isolated rats. Furthermore, there was a reduction in plasmatic serotonin content, and an increase in plasmatic kynurenine levels following social isolation, while no significant changes in serotonin turnover were observed. Taken together, our data provide novel insights in the neurobiological alterations underlying the comorbidity between psychosis and anxiety, and open new perspectives for multi-target therapies acting on both neurochemical and neuroendocrine pathways. Data availability statement: The data presented in this study are available on request from the corresponding author. |
| first_indexed | 2024-04-10T22:58:43Z |
| format | Article |
| id | doaj.art-19de1ecd03934c98a2251b0a4d07dfcd |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T22:58:43Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-19de1ecd03934c98a2251b0a4d07dfcd2023-01-14T04:26:06ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-02-01158114181Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctionsStefania Dimonte0Vladyslav Sikora1Maria Bove2Maria Grazia Morgese3Paolo Tucci4Stefania Schiavone5Luigia Trabace6Departement of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122, Foggia, ItalyDepartement of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122, Foggia, Italy; Department of Pathology, Sumy State University, 2, Rymskogo-Korsakova st., Sumy 40007, UkraineDepartement of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122, Foggia, ItalyDepartement of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122, Foggia, ItalyDepartement of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122, Foggia, ItalyDepartement of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122, Foggia, Italy; Corresponding author.Departement of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122, Foggia, ItalySubjects suffering from psychosis frequently experience anxiety. However, mechanisms underlying this comorbidity remain still unclear. We investigated whether neurochemical and neuroendocrine dysfunctions were involved in the development of anxiety-like behavior in a rodent model of psychotic-like symptoms, obtained by exposing male rats to social isolation rearing from postnatal day 21 to postnatal day 70. In the elevated zero maze test, isolated rats showed a significant reduction in the time spent in the open arms, as well as an increase in the time spent in the closed arms, compared to controls. An increased grooming time in the open field test was also observed in isolated animals. Isolation-induced anxiety-like behavior was accompanied by a decrease of plasmatic oxytocin, prolactin, ghrelin and melatonin levels, whereas plasmatic amount of Neuropeptide S was not altered. Social isolation also caused a reduction of noradrenaline, serotonin and GABA levels, together with an increase of serotonin turnover and glutamate levels in the amygdala of isolated animals. No significant differences were found in noradrenaline and serotonin levels, as well as in serotonin turnover in hippocampus, while glutamate amount was increased and GABA levels were reduced in isolated rats. Furthermore, there was a reduction in plasmatic serotonin content, and an increase in plasmatic kynurenine levels following social isolation, while no significant changes in serotonin turnover were observed. Taken together, our data provide novel insights in the neurobiological alterations underlying the comorbidity between psychosis and anxiety, and open new perspectives for multi-target therapies acting on both neurochemical and neuroendocrine pathways. Data availability statement: The data presented in this study are available on request from the corresponding author.http://www.sciencedirect.com/science/article/pii/S0753332222015700PsychosisAnxietySocial isolationNeurochemistryNeuroendocrine modulators |
| spellingShingle | Stefania Dimonte Vladyslav Sikora Maria Bove Maria Grazia Morgese Paolo Tucci Stefania Schiavone Luigia Trabace Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions Biomedicine & Pharmacotherapy Psychosis Anxiety Social isolation Neurochemistry Neuroendocrine modulators |
| title | Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions |
| title_full | Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions |
| title_fullStr | Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions |
| title_full_unstemmed | Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions |
| title_short | Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions |
| title_sort | social isolation from early life induces anxiety like behaviors in adult rats relation to neuroendocrine and neurochemical dysfunctions |
| topic | Psychosis Anxiety Social isolation Neurochemistry Neuroendocrine modulators |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222015700 |
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