Is intracranial volume a suitable proxy for brain reserve?
Abstract Background Brain reserve is a concept introduced to explain why Alzheimer’s disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss...
Main Authors: | Anna Catharina van Loenhoud, Colin Groot, Jacob William Vogel, Wiesje Maria van der Flier, Rik Ossenkoppele |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-09-01
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Series: | Alzheimer’s Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13195-018-0408-5 |
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