Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions
This study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants’ symptoms and resilien...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/11/3076 |
| _version_ | 1827640407384653824 |
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| author | Nada Lukkahatai Jongmin Park Hejingzi Monica Jia Daniel Martin Junxin Li Jennifer Yeong-Shin Sheng Jessica Gill Leorey N. Saligan Vered Stearns Michael Carducci |
| author_facet | Nada Lukkahatai Jongmin Park Hejingzi Monica Jia Daniel Martin Junxin Li Jennifer Yeong-Shin Sheng Jessica Gill Leorey N. Saligan Vered Stearns Michael Carducci |
| author_sort | Nada Lukkahatai |
| collection | DOAJ |
| description | This study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants’ symptoms and resilience were assessed, and peripheral blood was collected. DNA methylation age calculation was performed using DNAge<sup>®</sup> analysis. Data were analyzed using Spearman’s correlation analysis and the Mann–Whitney U test. Participants in the intervention group tended to have a decrease in DNA methylation age and age acceleration after completing an exercise program (mean difference = −0.83 ± 1.26). The change in DNA methylation age was significantly correlated with the change in resilience score (r = −0.897, <i>p</i> = 0.015). The preliminary results suggest that DNA methylation age can be a potential biomarker for improving resilience in cancer survivors with multiple chronic conditions. This finding is limited by the small sample size, and a larger study is needed. |
| first_indexed | 2024-03-09T16:59:15Z |
| format | Article |
| id | doaj.art-19e11f215f6c49058dff1e111441374e |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T16:59:15Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-19e11f215f6c49058dff1e111441374e2023-11-24T14:31:24ZengMDPI AGBiomedicines2227-90592023-11-011111307610.3390/biomedicines11113076Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic ConditionsNada Lukkahatai0Jongmin Park1Hejingzi Monica Jia2Daniel Martin3Junxin Li4Jennifer Yeong-Shin Sheng5Jessica Gill6Leorey N. Saligan7Vered Stearns8Michael Carducci9School of Nursing, Johns Hopkins University, Baltimore, MD 21205, USACollege of Nursing, Research Institute of Nursing Science, Pusan National University, Yangsan-si 50612, Republic of KoreaBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USASchool of Nursing, Johns Hopkins University, Baltimore, MD 21205, USASchool of Nursing, Johns Hopkins University, Baltimore, MD 21205, USAJohns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USASchool of Nursing, Johns Hopkins University, Baltimore, MD 21205, USANational Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892, USASchool of Medicine, Johns Hopkins University, Baltimore, MD 21205, USASchool of Medicine, Johns Hopkins University, Baltimore, MD 21205, USAThis study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants’ symptoms and resilience were assessed, and peripheral blood was collected. DNA methylation age calculation was performed using DNAge<sup>®</sup> analysis. Data were analyzed using Spearman’s correlation analysis and the Mann–Whitney U test. Participants in the intervention group tended to have a decrease in DNA methylation age and age acceleration after completing an exercise program (mean difference = −0.83 ± 1.26). The change in DNA methylation age was significantly correlated with the change in resilience score (r = −0.897, <i>p</i> = 0.015). The preliminary results suggest that DNA methylation age can be a potential biomarker for improving resilience in cancer survivors with multiple chronic conditions. This finding is limited by the small sample size, and a larger study is needed.https://www.mdpi.com/2227-9059/11/11/3076DNA methylation agebiomarkerssymptomresiliencecancer survivor |
| spellingShingle | Nada Lukkahatai Jongmin Park Hejingzi Monica Jia Daniel Martin Junxin Li Jennifer Yeong-Shin Sheng Jessica Gill Leorey N. Saligan Vered Stearns Michael Carducci Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions Biomedicines DNA methylation age biomarkers symptom resilience cancer survivor |
| title | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
| title_full | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
| title_fullStr | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
| title_full_unstemmed | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
| title_short | Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions |
| title_sort | feasibility of dna methylation age as a biomarker of symptoms and resilience among cancer survivors with multiple chronic conditions |
| topic | DNA methylation age biomarkers symptom resilience cancer survivor |
| url | https://www.mdpi.com/2227-9059/11/11/3076 |
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