The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective
Genital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing global health concern. Its remarkable ability to intertwine with cellular processes, from harnessing host machinery for replication to subverting antiviral defenses like autophagy and programmed cell death, exempl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/11/2195 |
| _version_ | 1797457526336258048 |
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| author | Hemant Borase Deepak Shukla |
| author_facet | Hemant Borase Deepak Shukla |
| author_sort | Hemant Borase |
| collection | DOAJ |
| description | Genital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing global health concern. Its remarkable ability to intertwine with cellular processes, from harnessing host machinery for replication to subverting antiviral defenses like autophagy and programmed cell death, exemplifies the intricate interplay at the heart of its pathogenesis. While the biomedical community has extensively researched antiviral interventions, the efficiency of these strategies in managing HSV-2 remains suboptimal. Recognizing this, attention has shifted toward leveraging host cellular components to regulate HSV-2 replication and influence the cell cycle. Furthermore, innovative interventional strategies—including drug repurposing, microbivacs, connecting the host microbiome, and exploiting natural secondary metabolites—are emerging as potential game changers. This review summarizes the key steps in HSV-2 pathogenesis and newly discovered cellular interactions, presenting the latest developments in the field, highlighting existing challenges, and offering a fresh perspective on HSV-2’s pathogenesis and the potential avenues for its treatment by targeting cellular proteins and pathways. |
| first_indexed | 2024-03-09T16:23:19Z |
| format | Article |
| id | doaj.art-19e312e87c0a47ebb4fd44afd5a8592f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T16:23:19Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-19e312e87c0a47ebb4fd44afd5a8592f2023-11-24T15:10:44ZengMDPI AGViruses1999-49152023-10-011511219510.3390/v15112195The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic PerspectiveHemant Borase0Deepak Shukla1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USADepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USAGenital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing global health concern. Its remarkable ability to intertwine with cellular processes, from harnessing host machinery for replication to subverting antiviral defenses like autophagy and programmed cell death, exemplifies the intricate interplay at the heart of its pathogenesis. While the biomedical community has extensively researched antiviral interventions, the efficiency of these strategies in managing HSV-2 remains suboptimal. Recognizing this, attention has shifted toward leveraging host cellular components to regulate HSV-2 replication and influence the cell cycle. Furthermore, innovative interventional strategies—including drug repurposing, microbivacs, connecting the host microbiome, and exploiting natural secondary metabolites—are emerging as potential game changers. This review summarizes the key steps in HSV-2 pathogenesis and newly discovered cellular interactions, presenting the latest developments in the field, highlighting existing challenges, and offering a fresh perspective on HSV-2’s pathogenesis and the potential avenues for its treatment by targeting cellular proteins and pathways.https://www.mdpi.com/1999-4915/15/11/2195genital herpesherpes simplex virus-2vaccinesantiviralsimmune responsemicrobiome |
| spellingShingle | Hemant Borase Deepak Shukla The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective Viruses genital herpes herpes simplex virus-2 vaccines antivirals immune response microbiome |
| title | The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective |
| title_full | The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective |
| title_fullStr | The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective |
| title_full_unstemmed | The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective |
| title_short | The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective |
| title_sort | interplay of genital herpes with cellular processes a pathogenesis and therapeutic perspective |
| topic | genital herpes herpes simplex virus-2 vaccines antivirals immune response microbiome |
| url | https://www.mdpi.com/1999-4915/15/11/2195 |
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