Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women
In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in <i>MT1B</i>, <i>GSTP1</i>, <i>ABCB1</i>, <i>NQO1</i>, <i>CRTC3</i>, <i>GPX1</i>, <i>SOD2</i>, <i>CAT</...
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/2227-9059/9/9/1105 |
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| author | Piotr Baszuk Paulina Stadnik Wojciech Marciniak Róża Derkacz Anna Jakubowska Cezary Cybulski Tomasz Huzarski Jacek Gronwald Tadeusz Dębniak Katarzyna Białkowska Sandra Pietrzak Józef Kładny Rodney J. Scott Jan Lubiński Marcin R. Lener |
| author_facet | Piotr Baszuk Paulina Stadnik Wojciech Marciniak Róża Derkacz Anna Jakubowska Cezary Cybulski Tomasz Huzarski Jacek Gronwald Tadeusz Dębniak Katarzyna Białkowska Sandra Pietrzak Józef Kładny Rodney J. Scott Jan Lubiński Marcin R. Lener |
| author_sort | Piotr Baszuk |
| collection | DOAJ |
| description | In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in <i>MT1B</i>, <i>GSTP1</i>, <i>ABCB1</i>, <i>NQO1</i>, <i>CRTC3</i>, <i>GPX1</i>, <i>SOD2</i>, <i>CAT</i>, <i>XRCC1</i>, <i>ERCC2</i> can be used as a marker for the detection of colorectal cancer (CRC) among Polish women. A retrospective case-control study of CRC included 83 CRC cases and 78 healthy controls. From each study participant pre-treatment peripheral blood was collected for As level measurement by inductively coupled–plasma mass spectrometry (ICP-MS). We estimated the odds ratio (OR) of the association between blood-As levels and CRC using multivariable unconditional logistic regression models. A low blood-As level (0.27–0.67 µg/L) was associated with an increased frequency of CRC (OR: 3.69; <i>p</i> = 0.005). This correlation was significantly greater when participants carried particular gene variants: <i>CAT</i>, rs1001179-nonCC (OR: 19.4; <i>p</i> = 0.001); <i>ABCB1</i> rs2032582–CC (OR: 14.8; <i>p</i> = 0.024); <i>GPX1</i> rs1050450-CC (OR: 11.6; <i>p</i> = 0.002) and <i>CRTC3</i> rs12915189-nonGG (OR: 10.3; <i>p</i> = 0.003). Our study provides strong evidence that low blood-As levels are significantly associated with increased CRC occurrence and that particular gene variants significantly enhanced this correlation however, due to the novelty of these findings, we suggest further validation before a definitive statement that the combined effect of low blood-As levels with specific gene polymorphisms is a suitable CRC biomarker. |
| first_indexed | 2024-03-10T07:52:55Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T07:52:55Z |
| publishDate | 2021-08-01 |
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| series | Biomedicines |
| spelling | doaj.art-19e3535fe2be4e0181e222954ea259572023-11-22T12:07:02ZengMDPI AGBiomedicines2227-90592021-08-0199110510.3390/biomedicines9091105Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in WomenPiotr Baszuk0Paulina Stadnik1Wojciech Marciniak2Róża Derkacz3Anna Jakubowska4Cezary Cybulski5Tomasz Huzarski6Jacek Gronwald7Tadeusz Dębniak8Katarzyna Białkowska9Sandra Pietrzak10Józef Kładny11Rodney J. Scott12Jan Lubiński13Marcin R. Lener14International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of General Surgery and Surgical Oncology, First Clinical Hospital of Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandPriority Research Centre for Cancer Research, Innovation and Translation, Hunter Medical Research Institute, New Lambton Heights, NSW 2308, AustraliaInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, PolandIn following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in <i>MT1B</i>, <i>GSTP1</i>, <i>ABCB1</i>, <i>NQO1</i>, <i>CRTC3</i>, <i>GPX1</i>, <i>SOD2</i>, <i>CAT</i>, <i>XRCC1</i>, <i>ERCC2</i> can be used as a marker for the detection of colorectal cancer (CRC) among Polish women. A retrospective case-control study of CRC included 83 CRC cases and 78 healthy controls. From each study participant pre-treatment peripheral blood was collected for As level measurement by inductively coupled–plasma mass spectrometry (ICP-MS). We estimated the odds ratio (OR) of the association between blood-As levels and CRC using multivariable unconditional logistic regression models. A low blood-As level (0.27–0.67 µg/L) was associated with an increased frequency of CRC (OR: 3.69; <i>p</i> = 0.005). This correlation was significantly greater when participants carried particular gene variants: <i>CAT</i>, rs1001179-nonCC (OR: 19.4; <i>p</i> = 0.001); <i>ABCB1</i> rs2032582–CC (OR: 14.8; <i>p</i> = 0.024); <i>GPX1</i> rs1050450-CC (OR: 11.6; <i>p</i> = 0.002) and <i>CRTC3</i> rs12915189-nonGG (OR: 10.3; <i>p</i> = 0.003). Our study provides strong evidence that low blood-As levels are significantly associated with increased CRC occurrence and that particular gene variants significantly enhanced this correlation however, due to the novelty of these findings, we suggest further validation before a definitive statement that the combined effect of low blood-As levels with specific gene polymorphisms is a suitable CRC biomarker.https://www.mdpi.com/2227-9059/9/9/1105colorectal cancerarsenic levelbiomarkers |
| spellingShingle | Piotr Baszuk Paulina Stadnik Wojciech Marciniak Róża Derkacz Anna Jakubowska Cezary Cybulski Tomasz Huzarski Jacek Gronwald Tadeusz Dębniak Katarzyna Białkowska Sandra Pietrzak Józef Kładny Rodney J. Scott Jan Lubiński Marcin R. Lener Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women Biomedicines colorectal cancer arsenic level biomarkers |
| title | Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women |
| title_full | Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women |
| title_fullStr | Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women |
| title_full_unstemmed | Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women |
| title_short | Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women |
| title_sort | low blood as levels and selected genotypes appears to be promising biomarkers for occurrence of colorectal cancer in women |
| topic | colorectal cancer arsenic level biomarkers |
| url | https://www.mdpi.com/2227-9059/9/9/1105 |
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