Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis
Background: Several studies have reported prolonged symptoms especially neurological symptoms following acute infection in patients with COVID-19, known as long COVID-19. There are only few studies investigating this population and relatively less known, including nervous system involvement. A syste...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122001575 |
| _version_ | 1818018829816561664 |
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| author | Rizaldy Taslim Pinzon Vincent Ongko Wijaya Abraham Al Jody Patrick Nalla Nunsio Ranbebasa Bijak Buana |
| author_facet | Rizaldy Taslim Pinzon Vincent Ongko Wijaya Abraham Al Jody Patrick Nalla Nunsio Ranbebasa Bijak Buana |
| author_sort | Rizaldy Taslim Pinzon |
| collection | DOAJ |
| description | Background: Several studies have reported prolonged symptoms especially neurological symptoms following acute infection in patients with COVID-19, known as long COVID-19. There are only few studies investigating this population and relatively less known, including nervous system involvement. A systematic review and meta-analysis of these studies are required to understanding the prevalence of persistent neurological manifestations after COVID-19. Objective: To conduct a systematic review and meta-analysis on the persistent neurological manifestations in COVID-19 survivors. Methods: Authors conducted a literature search through PubMed and MedRxiv from January 1st, 2020 to October 2021 according to PRISMA guideline. Furthermore, the authors added additional sources by reviewing related references. Studies presenting the neurologic features of long COVID-19 patients in their data were included. Case reports and case series also included in this review. The quality of the studies was assessed based on the Oxford Centre for Evidence-Based Medicine guidelines. Selected studies were included in the meta-analysis of proportion and heterogeneity test. Findings: From 128 identified studies, 36 were eligible, with 9944 participants included. Most of the included studies had mean duration of follow-up after COVID-19 onset of less than 6 months. Fatigue was the most common (52.8%, 95%CI 19.9 – 84.4) symptoms of long COVID, followed by cognitive disorder (35.4%, 95%CI 2.1 – 81.7); paresthesia (33.3%, 95%CI 2.7 – 76.6); sleep disorder (32.9%, 95%CI 6.5 – 67.4); musculoskeletal pain (27.8%, 95%CI 12.7 – 46); and dizziness (26.4%, 95%CI 4.6 – 57.9). Conclusion: Neurological manifestations are prevalent and persisting in patients with long COVID. The duration of the symptoms are vary among literatures. However, the frequency are mostly observed during the first six months after the illness onset. |
| first_indexed | 2024-04-14T07:44:59Z |
| format | Article |
| id | doaj.art-19e353940bfc49e687227bb0914fbe60 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-14T07:44:59Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-19e353940bfc49e687227bb0914fbe602022-12-22T02:05:23ZengElsevierJournal of Infection and Public Health1876-03412022-08-01158856869Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysisRizaldy Taslim Pinzon0Vincent Ongko Wijaya1Abraham Al Jody2Patrick Nalla Nunsio3Ranbebasa Bijak Buana4Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, Indonesia; Neurology Department, Bethesda Hospital, Yogyakarta, Indonesia; Correspondence to: Faculty of Medicine Duta Wacana Christian University, Dr. Wahidin Sudirohusodo street, Yogyakarta 55224, Indonesia.Faculty of Medicine, Duta Wacana Christian University, Yogyakarta, IndonesiaFaculty of Medicine, Duta Wacana Christian University, Yogyakarta, IndonesiaFaculty of Medicine, Duta Wacana Christian University, Yogyakarta, IndonesiaFaculty of Medicine, Duta Wacana Christian University, Yogyakarta, IndonesiaBackground: Several studies have reported prolonged symptoms especially neurological symptoms following acute infection in patients with COVID-19, known as long COVID-19. There are only few studies investigating this population and relatively less known, including nervous system involvement. A systematic review and meta-analysis of these studies are required to understanding the prevalence of persistent neurological manifestations after COVID-19. Objective: To conduct a systematic review and meta-analysis on the persistent neurological manifestations in COVID-19 survivors. Methods: Authors conducted a literature search through PubMed and MedRxiv from January 1st, 2020 to October 2021 according to PRISMA guideline. Furthermore, the authors added additional sources by reviewing related references. Studies presenting the neurologic features of long COVID-19 patients in their data were included. Case reports and case series also included in this review. The quality of the studies was assessed based on the Oxford Centre for Evidence-Based Medicine guidelines. Selected studies were included in the meta-analysis of proportion and heterogeneity test. Findings: From 128 identified studies, 36 were eligible, with 9944 participants included. Most of the included studies had mean duration of follow-up after COVID-19 onset of less than 6 months. Fatigue was the most common (52.8%, 95%CI 19.9 – 84.4) symptoms of long COVID, followed by cognitive disorder (35.4%, 95%CI 2.1 – 81.7); paresthesia (33.3%, 95%CI 2.7 – 76.6); sleep disorder (32.9%, 95%CI 6.5 – 67.4); musculoskeletal pain (27.8%, 95%CI 12.7 – 46); and dizziness (26.4%, 95%CI 4.6 – 57.9). Conclusion: Neurological manifestations are prevalent and persisting in patients with long COVID. The duration of the symptoms are vary among literatures. However, the frequency are mostly observed during the first six months after the illness onset.http://www.sciencedirect.com/science/article/pii/S1876034122001575NeurologyLong covidManifestation |
| spellingShingle | Rizaldy Taslim Pinzon Vincent Ongko Wijaya Abraham Al Jody Patrick Nalla Nunsio Ranbebasa Bijak Buana Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis Journal of Infection and Public Health Neurology Long covid Manifestation |
| title | Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis |
| title_full | Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis |
| title_fullStr | Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis |
| title_full_unstemmed | Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis |
| title_short | Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis |
| title_sort | persistent neurological manifestations in long covid 19 syndrome a systematic review and meta analysis |
| topic | Neurology Long covid Manifestation |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122001575 |
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