Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvarium
BACKGROUND: Fracture healing is one of the important issues in medicine and veterinary. Therefore, finding new tech-niques with fewer side effects and faster healing is taken into consideration. OBJECTIVES: This study was conducted to evaluate the effect of the composites of micro ostrich eggshell...
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| Format: | Article |
| Language: | English |
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University of Tehran
2021-02-01
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| Series: | Iranian Journal of Veterinary Medicine |
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| Online Access: | https://ijvm.ut.ac.ir/article_81071_9a60475359a5daaced901667d61e12e5.pdf |
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| author | sara Habibnezhad Arabi Hamid Reza Moslemi Sahar Ghafari Khaligh |
| author_facet | sara Habibnezhad Arabi Hamid Reza Moslemi Sahar Ghafari Khaligh |
| author_sort | sara Habibnezhad Arabi |
| collection | DOAJ |
| description | BACKGROUND: Fracture healing is one of the important issues in medicine and veterinary. Therefore, finding new tech-niques with fewer side effects and faster healing is taken into consideration. OBJECTIVES: This study was conducted to evaluate the effect of the composites of micro ostrich eggshell (μ-OES) and hydroxyapatite (HA) composite on the healing of bone defect in rat calvarium. METHODS: Defects of 7 mm were made by a trephine in the calvaria of 45 male Wistar rats. The animals were divided into three groups and the defects in each group were filled with micro-composites that contained ostrich eggshell or HA or were left empty. The animals were euthanized at three different time points of 14, 28, and 42 days post-operation. Histological and serological assessments, such as measuring alkaline phosphatase were carried out at the same time points. RESULTS: Significant differences were observed in the granulation tissue formation of the treatment and control groups 14 days post-operation (p ≤0.05). The difference between μ-OES and HA treatment groups was not statistically significant (p >0.05). On days 28 and 42, there were no significant differences between the groups. However, in the center of the defect, the mean of healing in the μOES group was higher than the two other groups. CONCLUSIONS: In conclusion, the results of this study indicated the potential efficacy of μOES as a bone substitute in a rat calvarial defect model |
| first_indexed | 2024-12-17T06:07:16Z |
| format | Article |
| id | doaj.art-19e481d1c7f44993833c9723e7d27f03 |
| institution | Directory Open Access Journal |
| issn | 2251-8894 2252-0554 |
| language | English |
| last_indexed | 2024-12-17T06:07:16Z |
| publishDate | 2021-02-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Iranian Journal of Veterinary Medicine |
| spelling | doaj.art-19e481d1c7f44993833c9723e7d27f032022-12-21T22:00:44ZengUniversity of TehranIranian Journal of Veterinary Medicine2251-88942252-05542021-02-01151162610.22059/ijvm.2020.294423.100505481071Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvariumsara Habibnezhad Arabi0Hamid Reza Moslemi1Sahar Ghafari Khaligh2Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, IranDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, IranDepartment of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, IranBACKGROUND: Fracture healing is one of the important issues in medicine and veterinary. Therefore, finding new tech-niques with fewer side effects and faster healing is taken into consideration. OBJECTIVES: This study was conducted to evaluate the effect of the composites of micro ostrich eggshell (μ-OES) and hydroxyapatite (HA) composite on the healing of bone defect in rat calvarium. METHODS: Defects of 7 mm were made by a trephine in the calvaria of 45 male Wistar rats. The animals were divided into three groups and the defects in each group were filled with micro-composites that contained ostrich eggshell or HA or were left empty. The animals were euthanized at three different time points of 14, 28, and 42 days post-operation. Histological and serological assessments, such as measuring alkaline phosphatase were carried out at the same time points. RESULTS: Significant differences were observed in the granulation tissue formation of the treatment and control groups 14 days post-operation (p ≤0.05). The difference between μ-OES and HA treatment groups was not statistically significant (p >0.05). On days 28 and 42, there were no significant differences between the groups. However, in the center of the defect, the mean of healing in the μOES group was higher than the two other groups. CONCLUSIONS: In conclusion, the results of this study indicated the potential efficacy of μOES as a bone substitute in a rat calvarial defect modelhttps://ijvm.ut.ac.ir/article_81071_9a60475359a5daaced901667d61e12e5.pdfcalvariumhydroxyapatitehistopathologymicro ostrich eggshellrat |
| spellingShingle | sara Habibnezhad Arabi Hamid Reza Moslemi Sahar Ghafari Khaligh Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvarium Iranian Journal of Veterinary Medicine calvarium hydroxyapatite histopathology micro ostrich eggshell rat |
| title | Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvarium |
| title_full | Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvarium |
| title_fullStr | Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvarium |
| title_full_unstemmed | Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvarium |
| title_short | Comparative Study of Micro Ostrich Eggshell and Hydroxyapatite onthe Healing of Bone Defect Created in the Rat Calvarium |
| title_sort | comparative study of micro ostrich eggshell and hydroxyapatite onthe healing of bone defect created in the rat calvarium |
| topic | calvarium hydroxyapatite histopathology micro ostrich eggshell rat |
| url | https://ijvm.ut.ac.ir/article_81071_9a60475359a5daaced901667d61e12e5.pdf |
| work_keys_str_mv | AT sarahabibnezhadarabi comparativestudyofmicroostricheggshellandhydroxyapatiteonthehealingofbonedefectcreatedintheratcalvarium AT hamidrezamoslemi comparativestudyofmicroostricheggshellandhydroxyapatiteonthehealingofbonedefectcreatedintheratcalvarium AT saharghafarikhaligh comparativestudyofmicroostricheggshellandhydroxyapatiteonthehealingofbonedefectcreatedintheratcalvarium |