The Pleural Mesothelium in Development and Disease
The pleural mesothelium, derived from the embryonic mesoderm, is formed by a metabolically active monolayer of cells that blanket the chest wall and lungs on the parietal and visceral surfaces, respectively. The pleura and lungs are formed as a result of an intricate relationship between the mesoder...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00284/full |
| _version_ | 1818413527776362496 |
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| author | Hitesh eBatra Veena B Antony |
| author_facet | Hitesh eBatra Veena B Antony |
| author_sort | Hitesh eBatra |
| collection | DOAJ |
| description | The pleural mesothelium, derived from the embryonic mesoderm, is formed by a metabolically active monolayer of cells that blanket the chest wall and lungs on the parietal and visceral surfaces, respectively. The pleura and lungs are formed as a result of an intricate relationship between the mesoderm and the endoderm during development. Pleural Mesothelial Cells (PMCs) are known to express Wilms tumor-1 (Wt1) gene and in lineage labeling studies of the developing embryo, PMCs were found to track into the lung parenchyma and undergo mesothelial-mesenchymal transition (MMT) to form α-smooth muscle actin (α-SMA)-positive cells of the mesenchyme and vasculature. There is definite evidence that mesothelial cells can differentiate and this seems to play an important role in pleural and parenchymal pathologies. Mesothelial cells can differentiate into adipocytes, chondrocytes and osteoblasts; and have been shown to clonally generate fibroblasts and smooth muscle cells in murine models. This supports the possibility that they may also modulate lung injury-repair by re-activation of developmental programs in the adult reflecting an altered recapitulation of development, with implications for regenerative biology of the lung. |
| first_indexed | 2024-12-14T11:04:38Z |
| format | Article |
| id | doaj.art-19e5c05111f04f349f677102742a50d9 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T11:04:38Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-19e5c05111f04f349f677102742a50d92022-12-21T23:04:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-08-01510.3389/fphys.2014.00284102820The Pleural Mesothelium in Development and DiseaseHitesh eBatra0Veena B Antony1University of Alabama at BirminghamUniversity of Alabama at BirminghamThe pleural mesothelium, derived from the embryonic mesoderm, is formed by a metabolically active monolayer of cells that blanket the chest wall and lungs on the parietal and visceral surfaces, respectively. The pleura and lungs are formed as a result of an intricate relationship between the mesoderm and the endoderm during development. Pleural Mesothelial Cells (PMCs) are known to express Wilms tumor-1 (Wt1) gene and in lineage labeling studies of the developing embryo, PMCs were found to track into the lung parenchyma and undergo mesothelial-mesenchymal transition (MMT) to form α-smooth muscle actin (α-SMA)-positive cells of the mesenchyme and vasculature. There is definite evidence that mesothelial cells can differentiate and this seems to play an important role in pleural and parenchymal pathologies. Mesothelial cells can differentiate into adipocytes, chondrocytes and osteoblasts; and have been shown to clonally generate fibroblasts and smooth muscle cells in murine models. This supports the possibility that they may also modulate lung injury-repair by re-activation of developmental programs in the adult reflecting an altered recapitulation of development, with implications for regenerative biology of the lung.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00284/fullIdiopathic pulmonary fibrosis (IPF)Epithelial-mesenchymal transition (EMT)Pleural MesotheliumPleural Mesothelial CellsWilms Tumor -1 (WT1)Mesothelial-mesenchymal transition |
| spellingShingle | Hitesh eBatra Veena B Antony The Pleural Mesothelium in Development and Disease Frontiers in Physiology Idiopathic pulmonary fibrosis (IPF) Epithelial-mesenchymal transition (EMT) Pleural Mesothelium Pleural Mesothelial Cells Wilms Tumor -1 (WT1) Mesothelial-mesenchymal transition |
| title | The Pleural Mesothelium in Development and Disease |
| title_full | The Pleural Mesothelium in Development and Disease |
| title_fullStr | The Pleural Mesothelium in Development and Disease |
| title_full_unstemmed | The Pleural Mesothelium in Development and Disease |
| title_short | The Pleural Mesothelium in Development and Disease |
| title_sort | pleural mesothelium in development and disease |
| topic | Idiopathic pulmonary fibrosis (IPF) Epithelial-mesenchymal transition (EMT) Pleural Mesothelium Pleural Mesothelial Cells Wilms Tumor -1 (WT1) Mesothelial-mesenchymal transition |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00284/full |
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