Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset
Abstract Dopamine affects processing of temporal information, but most previous work has tested its role in prospective tasks, where participants know in advance when the event to be timed starts. However, we are often exposed to events whose onset we do not know in advance. We can evaluate their du...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47843-w |
| _version_ | 1797388388912857088 |
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| author | Ljubica Jovanovic Morgane Chassignolle Catherine Schmidt-Mutter Guillaume Behr Jennifer T. Coull Anne Giersch |
| author_facet | Ljubica Jovanovic Morgane Chassignolle Catherine Schmidt-Mutter Guillaume Behr Jennifer T. Coull Anne Giersch |
| author_sort | Ljubica Jovanovic |
| collection | DOAJ |
| description | Abstract Dopamine affects processing of temporal information, but most previous work has tested its role in prospective tasks, where participants know in advance when the event to be timed starts. However, we are often exposed to events whose onset we do not know in advance. We can evaluate their duration after they have elapsed, but mechanisms underlying this ability are still elusive. Here we contrasted effects of acute phenylalanine and tyrosine depletion (APTD) on both forms of timing in healthy volunteers, in a within-subject, placebo-controlled design. Participants were presented with a disc moving around a circular path and asked to reproduce the duration of one full revolution and to judge their confidence in performance. The onset of the revolution was either known in advance (explicit onset) or revealed only at the end of the trial (implicit onset). We found that APTD shortened reproduced durations in the explicit onset task but had no effect on temporal performance in the implicit onset task. This dissociation is corroborated by effects of APTD on confidence judgements in the explicit task only. Our findings suggest that dopamine has a specific role in prospective encoding of temporal intervals, rather than the processing of temporal information in general. |
| first_indexed | 2024-03-08T22:40:06Z |
| format | Article |
| id | doaj.art-19ea7f1536564f1bb0e27619f30b9bc1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:40:06Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-19ea7f1536564f1bb0e27619f30b9bc12023-12-17T12:12:07ZengNature PortfolioScientific Reports2045-23222023-12-0113111010.1038/s41598-023-47843-wDopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onsetLjubica Jovanovic0Morgane Chassignolle1Catherine Schmidt-Mutter2Guillaume Behr3Jennifer T. Coull4Anne Giersch5Inserm 1114, Centre for Psychiatry, University Hospital of Strasbourg, Strasbourg UniversityLaboratoire des Neurosciences Cognitives (LNC), Aix-Marseille University & CNRSCIC Inserm 1434, CHU StrasbourgInserm 1114, Centre for Psychiatry, University Hospital of Strasbourg, Strasbourg UniversityLaboratoire des Neurosciences Cognitives (LNC), Aix-Marseille University & CNRSInserm 1114, Centre for Psychiatry, University Hospital of Strasbourg, Strasbourg UniversityAbstract Dopamine affects processing of temporal information, but most previous work has tested its role in prospective tasks, where participants know in advance when the event to be timed starts. However, we are often exposed to events whose onset we do not know in advance. We can evaluate their duration after they have elapsed, but mechanisms underlying this ability are still elusive. Here we contrasted effects of acute phenylalanine and tyrosine depletion (APTD) on both forms of timing in healthy volunteers, in a within-subject, placebo-controlled design. Participants were presented with a disc moving around a circular path and asked to reproduce the duration of one full revolution and to judge their confidence in performance. The onset of the revolution was either known in advance (explicit onset) or revealed only at the end of the trial (implicit onset). We found that APTD shortened reproduced durations in the explicit onset task but had no effect on temporal performance in the implicit onset task. This dissociation is corroborated by effects of APTD on confidence judgements in the explicit task only. Our findings suggest that dopamine has a specific role in prospective encoding of temporal intervals, rather than the processing of temporal information in general.https://doi.org/10.1038/s41598-023-47843-w |
| spellingShingle | Ljubica Jovanovic Morgane Chassignolle Catherine Schmidt-Mutter Guillaume Behr Jennifer T. Coull Anne Giersch Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset Scientific Reports |
| title | Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset |
| title_full | Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset |
| title_fullStr | Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset |
| title_full_unstemmed | Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset |
| title_short | Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset |
| title_sort | dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit but not an implicit onset |
| url | https://doi.org/10.1038/s41598-023-47843-w |
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