Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair
The lack of vascular tissue and the low metabolism and biological activity of mature chondrocytes lead to the low regeneration ability of articular cartilage. People try to solve this problem through various methods, but the effect is not very ideal. Inspired by the piezoelectric effect of collagen...
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1165 |
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| author | Jiahang Wu Taijun Chen Yingying Wang Jiafan Bai Chenwen Lao Minyue Luo Mingxia Chen Wenzhen Peng Wei Zhi Jie Weng Jianxin Wang |
| author_facet | Jiahang Wu Taijun Chen Yingying Wang Jiafan Bai Chenwen Lao Minyue Luo Mingxia Chen Wenzhen Peng Wei Zhi Jie Weng Jianxin Wang |
| author_sort | Jiahang Wu |
| collection | DOAJ |
| description | The lack of vascular tissue and the low metabolism and biological activity of mature chondrocytes lead to the low regeneration ability of articular cartilage. People try to solve this problem through various methods, but the effect is not very ideal. Inspired by the piezoelectric effect of collagen in cartilage tissue, this work focused on the design of a biomimetic hydrogel by introducing piezoelectric materials and silver nanowires into hydrogel to endow them with piezoelectric and antibacterial properties to promote tissue regeneration. Additionally, the mechanical and swelling properties of the material were adjusted to match natural articular cartilage. Based on bionic principles, a double-layer piezoelectric hydrogel was prepared and applied for the repair of osteochondral defects. An enhanced repair effect of osteochondral defects has been seen, which has demonstrated potential values for future application in bionics principle- and piezoelectric effect-based osteochondral tissue engineering. Furthermore, piezoelectric effect-induced degradation was observed. These results fully indicated the positive effect of the piezoelectric effect on promoting the regeneration of osteochondral tissue and in vivo degradation of materials. |
| first_indexed | 2024-03-10T03:16:14Z |
| format | Article |
| id | doaj.art-19eab642b76b41e2a67b17728d423bd4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:16:14Z |
| publishDate | 2022-05-01 |
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| series | Biomedicines |
| spelling | doaj.art-19eab642b76b41e2a67b17728d423bd42023-11-23T10:12:01ZengMDPI AGBiomedicines2227-90592022-05-01105116510.3390/biomedicines10051165Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect RepairJiahang Wu0Taijun Chen1Yingying Wang2Jiafan Bai3Chenwen Lao4Minyue Luo5Mingxia Chen6Wenzhen Peng7Wei Zhi8Jie Weng9Jianxin Wang10Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaChengdu Yikeda Biotechnology Co., Ltd., Chengdu 610095, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaThe lack of vascular tissue and the low metabolism and biological activity of mature chondrocytes lead to the low regeneration ability of articular cartilage. People try to solve this problem through various methods, but the effect is not very ideal. Inspired by the piezoelectric effect of collagen in cartilage tissue, this work focused on the design of a biomimetic hydrogel by introducing piezoelectric materials and silver nanowires into hydrogel to endow them with piezoelectric and antibacterial properties to promote tissue regeneration. Additionally, the mechanical and swelling properties of the material were adjusted to match natural articular cartilage. Based on bionic principles, a double-layer piezoelectric hydrogel was prepared and applied for the repair of osteochondral defects. An enhanced repair effect of osteochondral defects has been seen, which has demonstrated potential values for future application in bionics principle- and piezoelectric effect-based osteochondral tissue engineering. Furthermore, piezoelectric effect-induced degradation was observed. These results fully indicated the positive effect of the piezoelectric effect on promoting the regeneration of osteochondral tissue and in vivo degradation of materials.https://www.mdpi.com/2227-9059/10/5/1165piezoelectric effectbiomimetic hydrogelantibacterialcartilage tissuetissue regeneration |
| spellingShingle | Jiahang Wu Taijun Chen Yingying Wang Jiafan Bai Chenwen Lao Minyue Luo Mingxia Chen Wenzhen Peng Wei Zhi Jie Weng Jianxin Wang Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair Biomedicines piezoelectric effect biomimetic hydrogel antibacterial cartilage tissue tissue regeneration |
| title | Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair |
| title_full | Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair |
| title_fullStr | Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair |
| title_full_unstemmed | Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair |
| title_short | Piezoelectric Effect of Antibacterial Biomimetic Hydrogel Promotes Osteochondral Defect Repair |
| title_sort | piezoelectric effect of antibacterial biomimetic hydrogel promotes osteochondral defect repair |
| topic | piezoelectric effect biomimetic hydrogel antibacterial cartilage tissue tissue regeneration |
| url | https://www.mdpi.com/2227-9059/10/5/1165 |
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