Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin
Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2010-06-01
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| Series: | RUDN Journal of Medicine |
| Subjects: | |
| Online Access: | http://journals.rudn.ru/medicine/article/view/2869 |
| _version_ | 1819078505849159680 |
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| author | Е V Kobolev V V Desyatsky L S Godlevsky V F Mustyatsu G А Drozdova |
| author_facet | Е V Kobolev V V Desyatsky L S Godlevsky V F Mustyatsu G А Drozdova |
| author_sort | Е V Kobolev |
| collection | DOAJ |
| description | Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner. |
| first_indexed | 2024-12-21T19:14:10Z |
| format | Article |
| id | doaj.art-19eb49e4ad9e435fb630059bab8d89db |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-12-21T19:14:10Z |
| publishDate | 2010-06-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-19eb49e4ad9e435fb630059bab8d89db2022-12-21T18:53:06ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612010-06-0102592869Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllinЕ V Kobolev0V V Desyatsky1L S Godlevsky2V F Mustyatsu3G А Drozdova4Одесский госмедуниверситетОдесский госмедуниверситетОдесский госмедуниверситетРоссийский университет дружбы народовОдесский госмедуниверситетUnder condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner.http://journals.rudn.ru/medicine/article/view/2869коразолформакологический киндлингбластная трансформациялимфоцитыпентоксифиллин |
| spellingShingle | Е V Kobolev V V Desyatsky L S Godlevsky V F Mustyatsu G А Drozdova Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin RUDN Journal of Medicine коразол формакологический киндлинг бластная трансформация лимфоциты пентоксифиллин |
| title | Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin |
| title_full | Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin |
| title_fullStr | Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin |
| title_full_unstemmed | Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin |
| title_short | Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin |
| title_sort | changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin |
| topic | коразол формакологический киндлинг бластная трансформация лимфоциты пентоксифиллин |
| url | http://journals.rudn.ru/medicine/article/view/2869 |
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