Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity
Aims: This study investigated the neurotoxic effects of prenatal alcohol and nicotine exposure in the cortex and hippocampus of rodents. Main methods: Behavioral alterations, electrophysiological changes, and biochemical markers associated with cholinergic neurotransmission, neural oxidative stress,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844019367040 |
| _version_ | 1818843236624498688 |
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| author | Dwipayan Bhattacharya Ayaka Fujihashi Mohammed Majrashi Jenna Bloemer Subhrajit Bhattacharya Manal Buabeid Martha Escobar Timothy Moore Vishnu Suppiramaniam Muralikrishnan Dhanasekaran |
| author_facet | Dwipayan Bhattacharya Ayaka Fujihashi Mohammed Majrashi Jenna Bloemer Subhrajit Bhattacharya Manal Buabeid Martha Escobar Timothy Moore Vishnu Suppiramaniam Muralikrishnan Dhanasekaran |
| author_sort | Dwipayan Bhattacharya |
| collection | DOAJ |
| description | Aims: This study investigated the neurotoxic effects of prenatal alcohol and nicotine exposure in the cortex and hippocampus of rodents. Main methods: Behavioral alterations, electrophysiological changes, and biochemical markers associated with cholinergic neurotransmission, neural oxidative stress, mitochondrial function, and apoptosis were evaluated. Key findings: Prenatal alcohol exposure induced the generation of ROS, nitrite and lipid peroxide, decreased mitochondrial Complex-I and IV activities, increased Caspase-1 and 3 activities, had no effect on cholinergic neurotransmission, increased expression of PSD-95, decreased LTP and decreased performance on spatial memory tasks. However, nicotine exposure, in addition to alcohol exposure, was found to mitigate the negative effects of alcohol alone on ROS generation and spatial memory task performances. Furthermore, we also studied the role of ILK in prenatal alcohol and nicotine exposure. Significance: Prenatal Smoking and/or drinking is a major health concern around the world. Thus, our current study may lead to better insights into the molecular mechanisms of fetal alcohol and nicotine exposure on the developing offspring. |
| first_indexed | 2024-12-19T04:54:40Z |
| format | Article |
| id | doaj.art-19eb5b4938654504b6c90058dc5e62ca |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-19T04:54:40Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-19eb5b4938654504b6c90058dc5e62ca2022-12-21T20:35:15ZengElsevierHeliyon2405-84402020-01-0161e03045Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicityDwipayan Bhattacharya0Ayaka Fujihashi1Mohammed Majrashi2Jenna Bloemer3Subhrajit Bhattacharya4Manal Buabeid5Martha Escobar6Timothy Moore7Vishnu Suppiramaniam8Muralikrishnan Dhanasekaran9Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaCorresponding author.; Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, Faculty of Medicine, University of Jeddah, Jeddah, 23881, Saudi Arabia; Department of Psychology, Auburn University, Auburn, Alabama, United States of AmericaAims: This study investigated the neurotoxic effects of prenatal alcohol and nicotine exposure in the cortex and hippocampus of rodents. Main methods: Behavioral alterations, electrophysiological changes, and biochemical markers associated with cholinergic neurotransmission, neural oxidative stress, mitochondrial function, and apoptosis were evaluated. Key findings: Prenatal alcohol exposure induced the generation of ROS, nitrite and lipid peroxide, decreased mitochondrial Complex-I and IV activities, increased Caspase-1 and 3 activities, had no effect on cholinergic neurotransmission, increased expression of PSD-95, decreased LTP and decreased performance on spatial memory tasks. However, nicotine exposure, in addition to alcohol exposure, was found to mitigate the negative effects of alcohol alone on ROS generation and spatial memory task performances. Furthermore, we also studied the role of ILK in prenatal alcohol and nicotine exposure. Significance: Prenatal Smoking and/or drinking is a major health concern around the world. Thus, our current study may lead to better insights into the molecular mechanisms of fetal alcohol and nicotine exposure on the developing offspring.http://www.sciencedirect.com/science/article/pii/S2405844019367040NeuroscienceAgingMitochondrial functionOxidative stress |
| spellingShingle | Dwipayan Bhattacharya Ayaka Fujihashi Mohammed Majrashi Jenna Bloemer Subhrajit Bhattacharya Manal Buabeid Martha Escobar Timothy Moore Vishnu Suppiramaniam Muralikrishnan Dhanasekaran Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity Heliyon Neuroscience Aging Mitochondrial function Oxidative stress |
| title | Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity |
| title_full | Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity |
| title_fullStr | Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity |
| title_full_unstemmed | Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity |
| title_short | Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity |
| title_sort | concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity |
| topic | Neuroscience Aging Mitochondrial function Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2405844019367040 |
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