Manipulation of RNA polymerase III by Herpes Simplex Virus-1
RNA Polymerase III (Pol III) transcribes non-coding RNA, including tRNAs. Applying different RNA-Seq techniques, Dremel et al. provide the Pol III transcriptional landscape of Herpes simplex virus 1 (HSV-1) infected cells. Infection leads to an increase in tRNA expression from host euchromatin and P...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28144-8 |
| _version_ | 1798022555406172160 |
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| author | Sarah E. Dremel Frances L. Sivrich Jessica M. Tucker Britt A. Glaunsinger Neal A. DeLuca |
| author_facet | Sarah E. Dremel Frances L. Sivrich Jessica M. Tucker Britt A. Glaunsinger Neal A. DeLuca |
| author_sort | Sarah E. Dremel |
| collection | DOAJ |
| description | RNA Polymerase III (Pol III) transcribes non-coding RNA, including tRNAs. Applying different RNA-Seq techniques, Dremel et al. provide the Pol III transcriptional landscape of Herpes simplex virus 1 (HSV-1) infected cells. Infection leads to an increase in tRNA expression from host euchromatin and Pol II re-localization to tRNA loci. They also find that Pol III – associated factors bind to the viral genome. |
| first_indexed | 2024-04-11T17:31:57Z |
| format | Article |
| id | doaj.art-19f06cb5446848318ed03f2dfd3ad603 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T17:31:57Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-19f06cb5446848318ed03f2dfd3ad6032022-12-22T04:11:58ZengNature PortfolioNature Communications2041-17232022-02-0113111410.1038/s41467-022-28144-8Manipulation of RNA polymerase III by Herpes Simplex Virus-1Sarah E. Dremel0Frances L. Sivrich1Jessica M. Tucker2Britt A. Glaunsinger3Neal A. DeLuca4Department of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineDepartment of Plant and Microbial Biology, University of California BerkeleyDepartment of Plant and Microbial Biology, University of California BerkeleyDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineRNA Polymerase III (Pol III) transcribes non-coding RNA, including tRNAs. Applying different RNA-Seq techniques, Dremel et al. provide the Pol III transcriptional landscape of Herpes simplex virus 1 (HSV-1) infected cells. Infection leads to an increase in tRNA expression from host euchromatin and Pol II re-localization to tRNA loci. They also find that Pol III – associated factors bind to the viral genome.https://doi.org/10.1038/s41467-022-28144-8 |
| spellingShingle | Sarah E. Dremel Frances L. Sivrich Jessica M. Tucker Britt A. Glaunsinger Neal A. DeLuca Manipulation of RNA polymerase III by Herpes Simplex Virus-1 Nature Communications |
| title | Manipulation of RNA polymerase III by Herpes Simplex Virus-1 |
| title_full | Manipulation of RNA polymerase III by Herpes Simplex Virus-1 |
| title_fullStr | Manipulation of RNA polymerase III by Herpes Simplex Virus-1 |
| title_full_unstemmed | Manipulation of RNA polymerase III by Herpes Simplex Virus-1 |
| title_short | Manipulation of RNA polymerase III by Herpes Simplex Virus-1 |
| title_sort | manipulation of rna polymerase iii by herpes simplex virus 1 |
| url | https://doi.org/10.1038/s41467-022-28144-8 |
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