Francisella tularensis D-Ala D-Ala Carboxypeptidase DacD Is Involved in Intracellular Replication and It Is Necessary for Bacterial Cell Wall Integrity

Francisella tularensis D-Ala D-Ala Carboxypeptidase DacD Is Involved in Intracellular Replication and It Is Necessary for Bacterial Cell Wall Integrity

D-alanyl-D-alanine carboxypeptidase, product of dacD gene in Francisella, belongs to penicillin binding proteins (PBPs) and is involved in remodeling of newly synthetized peptidoglycan. In E. coli, PBPs are synthetized in various growth phases and they are able to substitute each other to a certain...

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Bibliographic Details
Main Authors: Petra Spidlova, Pavla Stojkova, Vera Dankova, Iva Senitkova, Marina Santic, Dominik Pinkas, Vlada Philimonenko, Jiri Stulik
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Francisella
DacD
virulence
phagosomal escape
carboxypeptidase
penicillin binding proteins
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00111/full

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