Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss

Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss

Pathogenic mutations in the Gjb2 and Gjb6 genes, encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, have been linked to the most frequent monogenic hearing impairment, nonsyndromic hearing loss, and deafness DFNB1. It is known that Cx26 plays an important role in auditory development,...

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Bibliographic Details
Main Authors: Fabiola Paciello, Veronica Zorzi, Marcello Raspa, Ferdinando Scavizzi, Claudio Grassi, Fabio Mammano, Anna Rita Fetoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
connexins
inner ear
inflammation
oxidative stress
vascular dysfunction
presbycusis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.950837/full

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