Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS
A GC-HRMS analytical method for the determination of 60 migrant substances, including aldehydes, ketones, phthalates and other plasticizers, phenol derivatives, acrylates, and methacrylates, in plastic food contact materials (FCM) has been developed and validated. The proposed method includes migrat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/24/7640 |
| _version_ | 1797502096983982080 |
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| author | Pablo Miralles Vicent Yusà Yovana Sanchís Clara Coscollà |
| author_facet | Pablo Miralles Vicent Yusà Yovana Sanchís Clara Coscollà |
| author_sort | Pablo Miralles |
| collection | DOAJ |
| description | A GC-HRMS analytical method for the determination of 60 migrant substances, including aldehydes, ketones, phthalates and other plasticizers, phenol derivatives, acrylates, and methacrylates, in plastic food contact materials (FCM) has been developed and validated. The proposed method includes migration tests, according to Commission Regulation (EU) 10/2011, using four food simulants (A, B, C, and D1), followed by vortex-assisted liquid–liquid extraction (VA-LLE) and GC-Q-Orbitrap HRMS analysis in selected ion monitoring (SIM) mode, with a resolving power of 30,000 FWHM and a mass accuracy ≤5 ppm. The method was validated, showing satisfactory linearity (R<sup>2</sup> ≥ 0.98 from 40 to 400 µg L<sup>−1</sup>), limits of quantification (40 µg L<sup>−1</sup>), precision (RSD, 0.6–12.6%), and relative recovery (81–120%). The proposed method was applied to the analysis of field samples, including an epoxy-coated tin food can, a drinking bottle made of Tritan copolyester, a disposable glass made of polycarbonate, and a baby feeding bottle made of polypropylene, showing that they were in compliance with the current European regulation regarding the studied substances. |
| first_indexed | 2024-03-10T03:28:00Z |
| format | Article |
| id | doaj.art-19f6946e8b024eab9db1906e4dc7798b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:28:00Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-19f6946e8b024eab9db1906e4dc7798b2023-11-23T09:47:08ZengMDPI AGMolecules1420-30492021-12-012624764010.3390/molecules26247640Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMSPablo Miralles0Vicent Yusà1Yovana Sanchís2Clara Coscollà3Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, SpainFoundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, SpainFoundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, SpainFoundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avinguda Catalunya 21, 46020 Valencia, SpainA GC-HRMS analytical method for the determination of 60 migrant substances, including aldehydes, ketones, phthalates and other plasticizers, phenol derivatives, acrylates, and methacrylates, in plastic food contact materials (FCM) has been developed and validated. The proposed method includes migration tests, according to Commission Regulation (EU) 10/2011, using four food simulants (A, B, C, and D1), followed by vortex-assisted liquid–liquid extraction (VA-LLE) and GC-Q-Orbitrap HRMS analysis in selected ion monitoring (SIM) mode, with a resolving power of 30,000 FWHM and a mass accuracy ≤5 ppm. The method was validated, showing satisfactory linearity (R<sup>2</sup> ≥ 0.98 from 40 to 400 µg L<sup>−1</sup>), limits of quantification (40 µg L<sup>−1</sup>), precision (RSD, 0.6–12.6%), and relative recovery (81–120%). The proposed method was applied to the analysis of field samples, including an epoxy-coated tin food can, a drinking bottle made of Tritan copolyester, a disposable glass made of polycarbonate, and a baby feeding bottle made of polypropylene, showing that they were in compliance with the current European regulation regarding the studied substances.https://www.mdpi.com/1420-3049/26/24/7640food contact materialsfood simulantsgas chromatographyhigh-resolution mass spectrometrymigration testtarget analysis |
| spellingShingle | Pablo Miralles Vicent Yusà Yovana Sanchís Clara Coscollà Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS Molecules food contact materials food simulants gas chromatography high-resolution mass spectrometry migration test target analysis |
| title | Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS |
| title_full | Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS |
| title_fullStr | Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS |
| title_full_unstemmed | Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS |
| title_short | Determination of 60 Migrant Substances in Plastic Food Contact Materials by Vortex-Assisted Liquid-Liquid Extraction and GC-Q-Orbitrap HRMS |
| title_sort | determination of 60 migrant substances in plastic food contact materials by vortex assisted liquid liquid extraction and gc q orbitrap hrms |
| topic | food contact materials food simulants gas chromatography high-resolution mass spectrometry migration test target analysis |
| url | https://www.mdpi.com/1420-3049/26/24/7640 |
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