Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis
A lack of physical activity is a generally accepted risk factor for colorectal cancer. However, research on the effect of preoperative physical activity on postoperative and long-term outcomes is limited, especially in patients with stage IV colorectal cancer who underwent palliative surgery. Patien...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/489 |
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| author | Ching-Chung Cheng I-Li Lai Shu-Huan Huang Wen-Sy Tsai Pao-Shiu Hsieh Chien-Yuh Yeh Sum-Fu Chiang Hsin-Yuan Hung Jeng-Fu You |
| author_facet | Ching-Chung Cheng I-Li Lai Shu-Huan Huang Wen-Sy Tsai Pao-Shiu Hsieh Chien-Yuh Yeh Sum-Fu Chiang Hsin-Yuan Hung Jeng-Fu You |
| author_sort | Ching-Chung Cheng |
| collection | DOAJ |
| description | A lack of physical activity is a generally accepted risk factor for colorectal cancer. However, research on the effect of preoperative physical activity on postoperative and long-term outcomes is limited, especially in patients with stage IV colorectal cancer who underwent palliative surgery. Patients who underwent bowel resection for stage IV primary colorectal cancer between January 1995 and December 2016 were retrospectively enrolled. A total of 2185 patients were divided into two groups according to preoperative leisure-time weekly physical activity as assessed by metabolic equivalent of task (MET) values: MET < 12 (<i>n</i> = 1845) and MET ≥ 12 (<i>n</i> = 340). Inverse probability of treatment weighting (IPTW) was used to reduce imbalance and selection biases between the two groups. After the IPTW process, the MET < 12 group showed a higher postoperative morbidity rate (18.7% vs. 10.6%; <i>p</i> < 0.001) and mortality rate (2.4% vs. 0.6%; <i>p</i> < 0.001) than the MET ≥ 12 group. No significant difference was found in overall survival. Weekly preoperative leisure-time physical activity with MET ≥ 12 was associated with reduced short-term postoperative morbidity and mortality in patients undergoing palliative resection for metastatic colorectal cancer. However, no difference was detected in long-term survival. |
| first_indexed | 2024-03-10T00:08:50Z |
| format | Article |
| id | doaj.art-19f6953e616341489f0b6d8588611f68 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:08:50Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-19f6953e616341489f0b6d8588611f682023-11-23T16:03:40ZengMDPI AGCancers2072-66942022-01-0114348910.3390/cancers14030489Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting AnalysisChing-Chung Cheng0I-Li Lai1Shu-Huan Huang2Wen-Sy Tsai3Pao-Shiu Hsieh4Chien-Yuh Yeh5Sum-Fu Chiang6Hsin-Yuan Hung7Jeng-Fu You8Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, New Taipei Municipal TuCheng Hospital, New Taipei City 236, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanA lack of physical activity is a generally accepted risk factor for colorectal cancer. However, research on the effect of preoperative physical activity on postoperative and long-term outcomes is limited, especially in patients with stage IV colorectal cancer who underwent palliative surgery. Patients who underwent bowel resection for stage IV primary colorectal cancer between January 1995 and December 2016 were retrospectively enrolled. A total of 2185 patients were divided into two groups according to preoperative leisure-time weekly physical activity as assessed by metabolic equivalent of task (MET) values: MET < 12 (<i>n</i> = 1845) and MET ≥ 12 (<i>n</i> = 340). Inverse probability of treatment weighting (IPTW) was used to reduce imbalance and selection biases between the two groups. After the IPTW process, the MET < 12 group showed a higher postoperative morbidity rate (18.7% vs. 10.6%; <i>p</i> < 0.001) and mortality rate (2.4% vs. 0.6%; <i>p</i> < 0.001) than the MET ≥ 12 group. No significant difference was found in overall survival. Weekly preoperative leisure-time physical activity with MET ≥ 12 was associated with reduced short-term postoperative morbidity and mortality in patients undergoing palliative resection for metastatic colorectal cancer. However, no difference was detected in long-term survival.https://www.mdpi.com/2072-6694/14/3/489colorectal cancerlong-term survivalmetabolic equivalent of taskphysical activityinverse probability of treatment weightingshort-term morbidity |
| spellingShingle | Ching-Chung Cheng I-Li Lai Shu-Huan Huang Wen-Sy Tsai Pao-Shiu Hsieh Chien-Yuh Yeh Sum-Fu Chiang Hsin-Yuan Hung Jeng-Fu You Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis Cancers colorectal cancer long-term survival metabolic equivalent of task physical activity inverse probability of treatment weighting short-term morbidity |
| title | Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis |
| title_full | Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis |
| title_fullStr | Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis |
| title_full_unstemmed | Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis |
| title_short | Association of Preoperative Physical Activity with Short- and Long-Term Outcomes in Patients Undergoing Palliative Resection for Metastatic Colorectal Cancer: An Inverse Probability of Treatment Weighting Analysis |
| title_sort | association of preoperative physical activity with short and long term outcomes in patients undergoing palliative resection for metastatic colorectal cancer an inverse probability of treatment weighting analysis |
| topic | colorectal cancer long-term survival metabolic equivalent of task physical activity inverse probability of treatment weighting short-term morbidity |
| url | https://www.mdpi.com/2072-6694/14/3/489 |
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