Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology
The paper is a self-review of works on development of new approaches to formation of mimics of receptor and catalytic sites of biological macromolecules in the structure of highly cross-linked polymer membranes and thin films. The general strategy for formation of the binding sites in molecularly im...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | BBA Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667160322000308 |
| _version_ | 1797797922158411776 |
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| author | Tetyana Sergeyeva Olena Piletska Sergiy Piletsky |
| author_facet | Tetyana Sergeyeva Olena Piletska Sergiy Piletsky |
| author_sort | Tetyana Sergeyeva |
| collection | DOAJ |
| description | The paper is a self-review of works on development of new approaches to formation of mimics of receptor and catalytic sites of biological macromolecules in the structure of highly cross-linked polymer membranes and thin films. The general strategy for formation of the binding sites in molecularly imprinted polymer (MIP) membranes and thin films was described. A selective recognition of a number of food toxins, endocrine disruptors and metabolites is based on the results of computational modeling data for the prediction and optimization of their structure. A strategy proposed for the design of the artificial binding sites in MIP membranes was supported by the research performed by the authors on development of a number of the MIP membrane-based affinity and catalytic biosensors for selective and sensitive measurement (detection limits 0.3–100 nM) of the target analytes. Novel versatile approaches aimed at improving sensitivity of the developed biosensor systems were discussed. |
| first_indexed | 2024-03-13T03:55:35Z |
| format | Article |
| id | doaj.art-19f77f2653d44645ab610ea094dabfcc |
| institution | Directory Open Access Journal |
| issn | 2667-1603 |
| language | English |
| last_indexed | 2024-03-13T03:55:35Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | BBA Advances |
| spelling | doaj.art-19f77f2653d44645ab610ea094dabfcc2023-06-22T05:05:50ZengElsevierBBA Advances2667-16032023-01-013100070Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnologyTetyana Sergeyeva0Olena Piletska1Sergiy Piletsky2Institute of Molecular Biology and Genetics, 150 Zabolotnogo str., 03680, Kyiv, Ukraine; Corresponding author.University of Leicester, Department of Chemistry, Leicester, University Road, Leicester, LE1 7RH, United KingdomUniversity of Leicester, Department of Chemistry, Leicester, University Road, Leicester, LE1 7RH, United KingdomThe paper is a self-review of works on development of new approaches to formation of mimics of receptor and catalytic sites of biological macromolecules in the structure of highly cross-linked polymer membranes and thin films. The general strategy for formation of the binding sites in molecularly imprinted polymer (MIP) membranes and thin films was described. A selective recognition of a number of food toxins, endocrine disruptors and metabolites is based on the results of computational modeling data for the prediction and optimization of their structure. A strategy proposed for the design of the artificial binding sites in MIP membranes was supported by the research performed by the authors on development of a number of the MIP membrane-based affinity and catalytic biosensors for selective and sensitive measurement (detection limits 0.3–100 nM) of the target analytes. Novel versatile approaches aimed at improving sensitivity of the developed biosensor systems were discussed.http://www.sciencedirect.com/science/article/pii/S2667160322000308Molecular recognitionBiomimetic polymersArtificial receptorsMolecularly imprinted polymer membranesBiosensorsSolid-phase extraction |
| spellingShingle | Tetyana Sergeyeva Olena Piletska Sergiy Piletsky Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology BBA Advances Molecular recognition Biomimetic polymers Artificial receptors Molecularly imprinted polymer membranes Biosensors Solid-phase extraction |
| title | Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology |
| title_full | Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology |
| title_fullStr | Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology |
| title_full_unstemmed | Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology |
| title_short | Rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology |
| title_sort | rationally designed molecularly imprinted polymer membranes as antibody and enzyme mimics in analytical biotechnology |
| topic | Molecular recognition Biomimetic polymers Artificial receptors Molecularly imprinted polymer membranes Biosensors Solid-phase extraction |
| url | http://www.sciencedirect.com/science/article/pii/S2667160322000308 |
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