Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication

Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication

Summary: Human cytomegalovirus (HCMV) replicates its DNA genome in specialized replication compartments (RCs) in the host cell nucleus. These membrane-less organelles originate as spherical structures and grow in size over time. However, the mechanism of RC biogenesis has remained understudied. Usin...

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Bibliographic Details
Main Authors: Enrico Caragliano, Stefano Bonazza, Giada Frascaroli, Jiajia Tang, Timothy K. Soh, Kay Grünewald, Jens B. Bosse, Wolfram Brune
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Cell Reports
Subjects:
liquid-liquid phase separation
LLPS
human cytomegalovirus
human herpesvirus 5
Herpesviridae
replication compartment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722002029

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http://www.sciencedirect.com/science/article/pii/S2211124722002029

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