Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy
Metabolic reprogramming enables cancer cells to proliferate and produce tumor biomass under a nutrient-deficient microenvironment and the stress of metabolic waste. A cancer cell adeptly undergoes a variety of adaptations in metabolic pathways and differential expression of metabolic enzyme genes. M...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/21/5268 |
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| author | Rishabh Kumar Anurag Mishra Priyanka Gautam Zainab Feroz Sivakumar Vijayaraghavalu Eviania M. Likos Girish C. Shukla Munish Kumar |
| author_facet | Rishabh Kumar Anurag Mishra Priyanka Gautam Zainab Feroz Sivakumar Vijayaraghavalu Eviania M. Likos Girish C. Shukla Munish Kumar |
| author_sort | Rishabh Kumar |
| collection | DOAJ |
| description | Metabolic reprogramming enables cancer cells to proliferate and produce tumor biomass under a nutrient-deficient microenvironment and the stress of metabolic waste. A cancer cell adeptly undergoes a variety of adaptations in metabolic pathways and differential expression of metabolic enzyme genes. Metabolic adaptation is mainly determined by the physiological demands of the cancer cell of origin and the host tissue. Numerous metabolic regulators that assist cancer cell proliferation include uncontrolled anabolism/catabolism of glucose metabolism, fatty acids, amino acids metabolism, nucleotide metabolism, tumor suppressor genes, microRNAs, and many regulatory enzymes and genes. Using this paradigm, we review the current understanding of metabolic reprogramming in tumors and discuss the new strategies of cancer metabolomics that can be tapped into for cancer therapeutics. |
| first_indexed | 2024-03-09T19:12:58Z |
| format | Article |
| id | doaj.art-19fb14d6dce440e8b8f7c59242928f5e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:12:58Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-19fb14d6dce440e8b8f7c59242928f5e2023-11-24T04:01:43ZengMDPI AGCancers2072-66942022-10-011421526810.3390/cancers14215268Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer TherapyRishabh Kumar0Anurag Mishra1Priyanka Gautam2Zainab Feroz3Sivakumar Vijayaraghavalu4Eviania M. Likos5Girish C. Shukla6Munish Kumar7Department of Biochemistry, Faculty of Science, University of Allahabad, Prayagraj 211002, UP, IndiaDepartment of Biochemistry, Faculty of Science, University of Allahabad, Prayagraj 211002, UP, IndiaDepartment of Biochemistry, Faculty of Science, University of Allahabad, Prayagraj 211002, UP, IndiaDepartment of Biochemistry, Faculty of Science, University of Allahabad, Prayagraj 211002, UP, IndiaDepartment of Life Sciences (Zoology), Manipur University, Imphal 795003, MN, IndiaCenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USACenter for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USADepartment of Biochemistry, Faculty of Science, University of Allahabad, Prayagraj 211002, UP, IndiaMetabolic reprogramming enables cancer cells to proliferate and produce tumor biomass under a nutrient-deficient microenvironment and the stress of metabolic waste. A cancer cell adeptly undergoes a variety of adaptations in metabolic pathways and differential expression of metabolic enzyme genes. Metabolic adaptation is mainly determined by the physiological demands of the cancer cell of origin and the host tissue. Numerous metabolic regulators that assist cancer cell proliferation include uncontrolled anabolism/catabolism of glucose metabolism, fatty acids, amino acids metabolism, nucleotide metabolism, tumor suppressor genes, microRNAs, and many regulatory enzymes and genes. Using this paradigm, we review the current understanding of metabolic reprogramming in tumors and discuss the new strategies of cancer metabolomics that can be tapped into for cancer therapeutics.https://www.mdpi.com/2072-6694/14/21/5268cancer metabolismglycolysisfatty acid metabolismamino acid metabolismWarburg effectmicroRNA |
| spellingShingle | Rishabh Kumar Anurag Mishra Priyanka Gautam Zainab Feroz Sivakumar Vijayaraghavalu Eviania M. Likos Girish C. Shukla Munish Kumar Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy Cancers cancer metabolism glycolysis fatty acid metabolism amino acid metabolism Warburg effect microRNA |
| title | Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy |
| title_full | Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy |
| title_fullStr | Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy |
| title_full_unstemmed | Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy |
| title_short | Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy |
| title_sort | metabolic pathways enzymes and metabolites opportunities in cancer therapy |
| topic | cancer metabolism glycolysis fatty acid metabolism amino acid metabolism Warburg effect microRNA |
| url | https://www.mdpi.com/2072-6694/14/21/5268 |
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