Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study
Objective: The present study was aimed to compare the effect of calcium channel blocker (Amlodipine, Cilnidipine and Diltiazem) on lipid profiles of hypertensive rats fed with high fat diet for four weeks. Methods: Hypertensive rats were randomly allocated into four groups and except hypertensive ra...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2016-12-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093116300011 |
| _version_ | 1797971535255830528 |
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| author | Nim Bahadur Dangi Akkiraju Sudheer S.P. Rathod Hari Prasad Sapkota |
| author_facet | Nim Bahadur Dangi Akkiraju Sudheer S.P. Rathod Hari Prasad Sapkota |
| author_sort | Nim Bahadur Dangi |
| collection | DOAJ |
| description | Objective: The present study was aimed to compare the effect of calcium channel blocker (Amlodipine, Cilnidipine and Diltiazem) on lipid profiles of hypertensive rats fed with high fat diet for four weeks.
Methods: Hypertensive rats were randomly allocated into four groups and except hypertensive rats remaining all groups received high fat diet for 4 weeks. At the end of protocol blood pressure was measured by tail cuff method and blood is withdrawn from the retro-orbital puncture, separated serum is used for the assessment of various biochemical parameters. Finally liver and aorta isolated for histological changes.
Results: Calcium channel blocker significantly reduces the lipid levels raised in hypertensive rats fed with high fat diet and also restore the pathological changes of aorta and liver tissues.
Conclusion: These results indicate that they have a lipid lowering effect due to effect on different stages of metabolism of lipids. |
| first_indexed | 2024-04-11T03:34:09Z |
| format | Article |
| id | doaj.art-19fdefb5685d4651a81ae964a2ebecbf |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T03:34:09Z |
| publishDate | 2016-12-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-19fdefb5685d4651a81ae964a2ebecbf2023-01-02T05:42:00ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312016-12-0154213714310.1016/j.bfopcu.2016.04.001Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative studyNim Bahadur Dangi0Akkiraju Sudheer1S.P. Rathod2Hari Prasad Sapkota3Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Krishnam Reddy Palli Cross, Chiyyedu, Anantapuramu 515721, Andhra Pradesh, IndiaDepartment of Pharmacology, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara 390001, Gujarat, IndiaDepartment of Pharmacology, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara 390001, Gujarat, IndiaDepartment of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Krishnam Reddy Palli Cross, Chiyyedu, Anantapuramu 515721, Andhra Pradesh, IndiaObjective: The present study was aimed to compare the effect of calcium channel blocker (Amlodipine, Cilnidipine and Diltiazem) on lipid profiles of hypertensive rats fed with high fat diet for four weeks. Methods: Hypertensive rats were randomly allocated into four groups and except hypertensive rats remaining all groups received high fat diet for 4 weeks. At the end of protocol blood pressure was measured by tail cuff method and blood is withdrawn from the retro-orbital puncture, separated serum is used for the assessment of various biochemical parameters. Finally liver and aorta isolated for histological changes. Results: Calcium channel blocker significantly reduces the lipid levels raised in hypertensive rats fed with high fat diet and also restore the pathological changes of aorta and liver tissues. Conclusion: These results indicate that they have a lipid lowering effect due to effect on different stages of metabolism of lipids.http://www.sciencedirect.com/science/article/pii/S1110093116300011Calcium channel blockersHypertensive ratsHigh fat dietHypolipidemic effect |
| spellingShingle | Nim Bahadur Dangi Akkiraju Sudheer S.P. Rathod Hari Prasad Sapkota Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study Bulletin of Faculty of Pharmacy Cairo University Calcium channel blockers Hypertensive rats High fat diet Hypolipidemic effect |
| title | Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study |
| title_full | Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study |
| title_fullStr | Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study |
| title_full_unstemmed | Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study |
| title_short | Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study |
| title_sort | effect of amlodipine cilnidipine and diltiazem on lipid profiles of hypertensive rats fed with high fat diet a comparative study |
| topic | Calcium channel blockers Hypertensive rats High fat diet Hypolipidemic effect |
| url | http://www.sciencedirect.com/science/article/pii/S1110093116300011 |
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