NMDA Receptor Modulators in the Treatment of Drug Addiction

NMDA Receptor Modulators in the Treatment of Drug Addiction

Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function, followed by a review of the mechanism of acti...

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Bibliographic Details
Main Authors: M. Foster Olive, Natali E. Nemirovsky, Seven E. Tomek, Amber L. Lacrosse
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Pharmaceuticals
Subjects:
glutamate
N-methyl-D-aspartate receptor
glycine binding site
antagonist
partial agonist
Online Access:http://www.mdpi.com/1424-8247/6/2/251

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