Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis
Abstract Background Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects of combined aerobic exercise and diet (AEDT) on various cardiometabol...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Sports Science, Medicine and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13102-023-00766-5 |
| _version_ | 1797397794887041024 |
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| author | Sameer Badri Al-Mhanna Sílvia Rocha-Rodriguesc Mahaneem Mohamed Alexios Batrakoulis Monira I. Aldhahi Hafeez Abiola Afolabi Fatma Hilal Yagin Maha H. Alhussain Mehmet Gülü Bishir Daku Abubakar Wan Syaheedah Wan Ghazali Abdullah F. Alghannam Georgian Badicu |
| author_facet | Sameer Badri Al-Mhanna Sílvia Rocha-Rodriguesc Mahaneem Mohamed Alexios Batrakoulis Monira I. Aldhahi Hafeez Abiola Afolabi Fatma Hilal Yagin Maha H. Alhussain Mehmet Gülü Bishir Daku Abubakar Wan Syaheedah Wan Ghazali Abdullah F. Alghannam Georgian Badicu |
| author_sort | Sameer Badri Al-Mhanna |
| collection | DOAJ |
| description | Abstract Background Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects of combined aerobic exercise and diet (AEDT) on various cardiometabolic health-related indicators among individuals with obesity and T2DM. Methodology A comprehensive search of the PubMed/Medline, Web of Science, Scopus, Science Direct, Cochrane, and Google Scholar databases was conducted for this meta-analysis. The Cochrane risk of bias tool was used to evaluate eligible studies, and the GRADE tool was used to rate the certainty of evidence. A random-effects model for continuous variables was used, and the results were presented as mean differences or standardised mean differences with 95% confidence intervals. Results A total of 16,129 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants. The findings revealed significant improvements in body mass index, body weight, waist circumference, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, fasting blood glucose, fasting plasma insulin, glycated hemoglobin, leptin, interleukin-6, C-reactive protein, and adiponectin (p < 0.05) compared to the standard treatment (ST) group. No significant differences were observed between the AEDT and ST groups in fat mass, hip circumference, waist-to-hip ratio, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and tumor necrosis factor-alpha. The present findings are based on low- to moderate-quality evidence. Conclusions AEDT may be a critical behavior for holistic cardiometabolic health-related benefits as a contemporary anti-obesity medication due to its significant positive impact on patients with obesity and T2DM. Nevertheless, further robust evidence is necessary to determine whether AEDT is an effective intervention for lowering cardiovascular and metabolic risk factors among individuals with obesity and T2DM. |
| first_indexed | 2024-03-09T01:16:17Z |
| format | Article |
| id | doaj.art-19fe8401b89e4dee8cfcfbeba6bfbc33 |
| institution | Directory Open Access Journal |
| issn | 2052-1847 |
| language | English |
| last_indexed | 2024-03-09T01:16:17Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Sports Science, Medicine and Rehabilitation |
| spelling | doaj.art-19fe8401b89e4dee8cfcfbeba6bfbc332023-12-10T12:28:02ZengBMCBMC Sports Science, Medicine and Rehabilitation2052-18472023-12-0115111510.1186/s13102-023-00766-5Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysisSameer Badri Al-Mhanna0Sílvia Rocha-Rodriguesc1Mahaneem Mohamed2Alexios Batrakoulis3Monira I. Aldhahi4Hafeez Abiola Afolabi5Fatma Hilal Yagin6Maha H. Alhussain7Mehmet Gülü8Bishir Daku Abubakar9Wan Syaheedah Wan Ghazali10Abdullah F. Alghannam11Georgian Badicu12Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha UniversityEscola Superior Desporto e Lazer, Instituto Politécnico de Viana do CasteloDepartment of Physiology, School of Medical Sciences, Universiti Sains MalaysiaDepartment of Physical Education and Sport Science, School of Physical Education, Sport Science and Dietetics, University of ThessalyDepartment of Rehabilitation, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman UniversityDepartment of General Surgery, School of Medical Sciences, Universiti Sains MalaysiaDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu UniversityDepartment of Food Science and Nutrition, College of Food and Agricultural Science, King Saud UniversityDepartment of Sports Management, Faculty of Sport Sciences, Kirikkale UniversityDepartment of Human Physiology, Federal University DutseDepartment of Physiology, School of Medical Sciences, Universiti Sains MalaysiaLifestyle and Health Research Center, Health Sciences Research Center, Princess Nourah bint Abdulrahman UniversityDepartment of Physical Education and Special Motricity, Transilvania University of BrasovAbstract Background Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects of combined aerobic exercise and diet (AEDT) on various cardiometabolic health-related indicators among individuals with obesity and T2DM. Methodology A comprehensive search of the PubMed/Medline, Web of Science, Scopus, Science Direct, Cochrane, and Google Scholar databases was conducted for this meta-analysis. The Cochrane risk of bias tool was used to evaluate eligible studies, and the GRADE tool was used to rate the certainty of evidence. A random-effects model for continuous variables was used, and the results were presented as mean differences or standardised mean differences with 95% confidence intervals. Results A total of 16,129 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants. The findings revealed significant improvements in body mass index, body weight, waist circumference, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, fasting blood glucose, fasting plasma insulin, glycated hemoglobin, leptin, interleukin-6, C-reactive protein, and adiponectin (p < 0.05) compared to the standard treatment (ST) group. No significant differences were observed between the AEDT and ST groups in fat mass, hip circumference, waist-to-hip ratio, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and tumor necrosis factor-alpha. The present findings are based on low- to moderate-quality evidence. Conclusions AEDT may be a critical behavior for holistic cardiometabolic health-related benefits as a contemporary anti-obesity medication due to its significant positive impact on patients with obesity and T2DM. Nevertheless, further robust evidence is necessary to determine whether AEDT is an effective intervention for lowering cardiovascular and metabolic risk factors among individuals with obesity and T2DM.https://doi.org/10.1186/s13102-023-00766-5Physical activityExerciseOverweightMetabolic syndromeLifestyle intervention |
| spellingShingle | Sameer Badri Al-Mhanna Sílvia Rocha-Rodriguesc Mahaneem Mohamed Alexios Batrakoulis Monira I. Aldhahi Hafeez Abiola Afolabi Fatma Hilal Yagin Maha H. Alhussain Mehmet Gülü Bishir Daku Abubakar Wan Syaheedah Wan Ghazali Abdullah F. Alghannam Georgian Badicu Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis BMC Sports Science, Medicine and Rehabilitation Physical activity Exercise Overweight Metabolic syndrome Lifestyle intervention |
| title | Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis |
| title_full | Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis |
| title_fullStr | Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis |
| title_full_unstemmed | Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis |
| title_short | Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis |
| title_sort | effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes a systematic review and meta analysis |
| topic | Physical activity Exercise Overweight Metabolic syndrome Lifestyle intervention |
| url | https://doi.org/10.1186/s13102-023-00766-5 |
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