Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation
Abstract Background Environmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. We assessed the association between the urinary concentrations of 11 phthalate metabolites and BPA with length of gestation in a cohort of women follow...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Environmental Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12940-019-0522-2 |
| _version_ | 1818851547815084032 |
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| author | Helen B. Chin Anne Marie Jukic Allen J. Wilcox Clarice R. Weinberg Kelly K. Ferguson Antonia M. Calafat D. Robert McConnaughey Donna D. Baird |
| author_facet | Helen B. Chin Anne Marie Jukic Allen J. Wilcox Clarice R. Weinberg Kelly K. Ferguson Antonia M. Calafat D. Robert McConnaughey Donna D. Baird |
| author_sort | Helen B. Chin |
| collection | DOAJ |
| description | Abstract Background Environmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. We assessed the association between the urinary concentrations of 11 phthalate metabolites and BPA with length of gestation in a cohort of women followed from before conception with daily 1st-morning urinary hormone measures that identified day of implantation. Methods Pre-implantation and post-implantation urinary phthalate metabolites and BPA concentrations were measured in pooled urine samples designed to limit single-measure variability due to the likely episodic nature of these exposures and the short half-life of these compounds. We estimated associations between these exposure biomarkers early in pregnancy with length of gestation from implantation to spontaneous birth. Cox proportional hazards models were used to estimate the hazard of birth among 125 naturally-conceived, singleton live births with censoring for medical interventions that artificially shortened pregnancy. Results Higher concentrations of mono (2-ethyl-5-hydroxyhexyl) phthalate (a metabolite of di (2-ethylhexyl) phthalate (DEHP)) during the pre-implantation window were associated with reduced probability of birth, i.e., longer gestations (hazard ratio (HR): 0.55, 95% CI: 0.35, 0.86; p = 0.01). The HR for the molar sum of the four DEHP metabolites measured showed a similar association (HR: 0.67, 95% CI: 0.43, 1.05). Higher concentrations of mono (3-carboxypropyl) phthalate (MCPP), a non-specific metabolite of several high molecular-weight phthalates, measured post-implantation were associated with increased risk of earlier birth, i.e. shorter length of gestation, HR: 1.59, CI: 1.02, 2.49. Conclusions Early gestational exposure to DEHP and possibly other high-molecular weight phthalates, (as reflected by urinary MCPP concentrations) may influence the length of pregnancy. Such effects could have consequences for neonatal and maternal health. |
| first_indexed | 2024-12-19T07:06:46Z |
| format | Article |
| id | doaj.art-19ffe0b5a6b14935b53d0c9ab5483d38 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-19T07:06:46Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-19ffe0b5a6b14935b53d0c9ab5483d382022-12-21T20:31:15ZengBMCEnvironmental Health1476-069X2019-08-011811810.1186/s12940-019-0522-2Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestationHelen B. Chin0Anne Marie Jukic1Allen J. Wilcox2Clarice R. Weinberg3Kelly K. Ferguson4Antonia M. Calafat5D. Robert McConnaughey6Donna D. Baird7Epidemiology Branch, National Institute of Environmental Health SciencesEpidemiology Branch, National Institute of Environmental Health SciencesEpidemiology Branch, National Institute of Environmental Health SciencesBiostatistics Branch, National Institute of Environmental Health SciencesEpidemiology Branch, National Institute of Environmental Health SciencesDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and PreventionWestatEpidemiology Branch, National Institute of Environmental Health SciencesAbstract Background Environmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. We assessed the association between the urinary concentrations of 11 phthalate metabolites and BPA with length of gestation in a cohort of women followed from before conception with daily 1st-morning urinary hormone measures that identified day of implantation. Methods Pre-implantation and post-implantation urinary phthalate metabolites and BPA concentrations were measured in pooled urine samples designed to limit single-measure variability due to the likely episodic nature of these exposures and the short half-life of these compounds. We estimated associations between these exposure biomarkers early in pregnancy with length of gestation from implantation to spontaneous birth. Cox proportional hazards models were used to estimate the hazard of birth among 125 naturally-conceived, singleton live births with censoring for medical interventions that artificially shortened pregnancy. Results Higher concentrations of mono (2-ethyl-5-hydroxyhexyl) phthalate (a metabolite of di (2-ethylhexyl) phthalate (DEHP)) during the pre-implantation window were associated with reduced probability of birth, i.e., longer gestations (hazard ratio (HR): 0.55, 95% CI: 0.35, 0.86; p = 0.01). The HR for the molar sum of the four DEHP metabolites measured showed a similar association (HR: 0.67, 95% CI: 0.43, 1.05). Higher concentrations of mono (3-carboxypropyl) phthalate (MCPP), a non-specific metabolite of several high molecular-weight phthalates, measured post-implantation were associated with increased risk of earlier birth, i.e. shorter length of gestation, HR: 1.59, CI: 1.02, 2.49. Conclusions Early gestational exposure to DEHP and possibly other high-molecular weight phthalates, (as reflected by urinary MCPP concentrations) may influence the length of pregnancy. Such effects could have consequences for neonatal and maternal health.http://link.springer.com/article/10.1186/s12940-019-0522-2PregnancyPregnancy lengthDelivery |
| spellingShingle | Helen B. Chin Anne Marie Jukic Allen J. Wilcox Clarice R. Weinberg Kelly K. Ferguson Antonia M. Calafat D. Robert McConnaughey Donna D. Baird Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation Environmental Health Pregnancy Pregnancy length Delivery |
| title | Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation |
| title_full | Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation |
| title_fullStr | Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation |
| title_full_unstemmed | Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation |
| title_short | Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation |
| title_sort | association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol a with length of gestation |
| topic | Pregnancy Pregnancy length Delivery |
| url | http://link.springer.com/article/10.1186/s12940-019-0522-2 |
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