BAFF blockade attenuates acute graft-versus-host disease directly via the dual regulation of T- and B-cell homeostasis

BAFF blockade attenuates acute graft-versus-host disease directly via the dual regulation of T- and B-cell homeostasis

IntroductionB-cell-activating factor (BAFF) is associated with donor-specific antibodies and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the effects of BAFF on T-cell physiological function have not been fully elucidated in...

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Bibliographic Details
Main Authors:	Youngwoo Jeon, Jung-Yeon Lim, Keon-Il Im, Nayoun Kim, Seok-Goo Cho
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Immunology
Subjects:	graft-versus-host disease hematopoietic stem cell transplantation B-cell-activating factor (BAFF) belimumab regulatory T-lymphocytes
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.995149/full

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